Adecard Injection 6mg/2ml

Adecard is an anti-arrhythmic medicine used to treat life-threatening arrhythmia (abnormal heart rhythm). It restores normal heart rhythm by blocking abnormal electrical signals in the heart. Adecard is also used to carry out diagnostic stress tests of the heart. It is administered under the supervision of a doctor. Your doctor will decide the dose and duration of the medicine for you. Doctor may closely monitor your blood pressure, heart rate and ECG till you became stable. You should continue all your other medicines that are advised by the doctor for your long-term treatment even after this injection. Common side effects of this medicine include flushing (sense of warmth in the face, ears, neck, and trunk), headache, chest pain, dizziness, and nausea. Consult your doctor if these effects bother you. This medicine is used with caution for some people. Thus, you must inform doctor if you are suffering from any kidney or liver disease. Also, let your doctor know if you are pregnant or breastfeeding and about all the other medications that you are taking regularly.

Pharmacology

This preparation is a sterile, nonpyrogenic solution for rapid bolus intravenous injection. Adenosine injection slows conduction time through the A-V node, can interrupt the reentry pathways through the A-V node, and can restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia.

Uses of Adecard

Arrhythmia

Side effects of Adecard

• Flushing (sense of warmth in the face, ears, neck and trunk)
• Dizziness
• Lightheadedness
• Nausea
• Numbness
• Tingling
• Chest pain

How to use Adecard

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Adecard works

Adecard is an anti-arrhythmic medication. It regulates heart beat by blocking abnormal electrical signals in the heart.

What if you forget to take Adecard?

If you miss a dose of Adecard, please consult your doctor.

Quick Tips

Food and drinks containing caffeine such as chocolate, coffee, and tea must be avoided for at least 12 hours before medicine use.

Stop taking medication and inform your doctor immediately if you experience a slow heartbeat, severe chest pain, and very low blood pressure.

Inform your doctor if you have a history of fits or problems with your heart.

Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Brief Description

Indication

Intravenous Differential diagnosis of supraventricular tachycardias Adult: Initially, 3 mg by rapid IV inj into a central or large peripheral vein over 2 sec with cardiac monitoring; 6 mg may be given after 1-2 minutes if necessary, then 12 mg after a further 1-2 minutes. Avoid increments if high level AV block occurs at any particular dose. Paroxysmal supraventricular tachycardia Adult: Initially, 3 mg by rapid IV inj into a central or large peripheral vein over 2 sec with cardiac monitoring; 6 mg may be given after 1-2 minutes if necessary, then 12 mg after a further 1-2 minutes. Avoid increments if high level AV block occurs at any particular dose. Myocardial imaging Adult: 140 mcg/kg/minute by infusion for 6 minutes. Inject radionuclide 3 minute after infusion.

Administration

Adenosine effects antagonised by methylxanthines like caffeine, theophylline, etc. Concomitant carbamazepine may increase the risk of heart block. Potentially Fatal: Adenosine effects are potentiated by dipyridamole.

Adult Dose

Pregnancy; heart transplant patients; patients on dipyridamole (lower initial dose of adenosine 0.5-1 mg); atrial fibrillation or flutter with accessory pathway (conduction along anomalous pathway may increase). Lactation: Potential for serious adverse reactions in nursing infants; decision to interrupt nursing after administration of adenosine or not should take into account importance of drug to mother.

Renal Dose

Adenosine acts rapidly to slow down conduction through the AV node via the A1 receptors. It also mediates peripheral and coronary vasodilatation by stimulating the A2 receptors. Extremely short plasma half-life (<10 sec) permits dosage titration during IV use every 1-2 min and causes no concern of cumulative effect through repeated dosing.

Contraindication

Intravenous Differential diagnosis of supraventricular tachycardias Child: Initially, 50-100 mcg/kg; if necessary, may increase dose by 50-100 mcg/kg increments at 1-2 minute intervals or until arrhythmia is controlled. Max dose: 300 mcg/kg. Paroxysmal supraventricular tachycardia Child: Initially, 50-100 mcg/kg; if necessary, may increase dose by 50-100 mcg/kg increments at 1-2 minute intervals or until arrhythmia is controlled. Max dose: 300 mcg/kg. Myocardial imaging Adult: 140 mcg/kg/minute by infusion for 6 minutes. Inject radionuclide 3 minute after infusion.

Mode of Action

IV Administration Adenocard: given as a rapid injection (1-3 sec) by peripheral IV route directly into vein or into IV line close (proximal) to patient & is followed by rapid NS flush after each inj (20 mL for adults, 5 mL or more for peds) Place pt in mild reverse Trendelenburg position before giving drug.

Precaution

Paroxysmal supraventricular tachycardia, Supraventricular tachycardia

Pregnancy Category Note

>10% Flushing (18%),Dyspnea (12%) 1-10% Chest pain (7%),HA (2%),Lightheadedness (2%), Dizziness (1%),Tingling in arms (1%),Numbness (1%),Nausea (3%) <1% Hypotension,Palpitations,Apprehension,Head pressure,Chest pain,Hyperventilation,Blurred vision,Burning sensation,Heaviness in arms, neck & back pain,Metallic taste,Tightness in throat,Pressure in groin,Sweating

Interaction

2nd or 3rd degree AV block and sick sinus syndrome (unless pacemaker fitted), asthma, hypersensitivity.

Storage Conditions

Store in cool dry place protected from light. Keep out of reach of children. Do not refrigerate as crystallization may occur. If crystallization has occurred, dissolve crystals by warming to room temperature. The solution must be clear at the time of use.