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Neumig 10mg Tablet
Neumig tablet is used for the treatment of:
- Neuropathic pain
- Diabetic peripheral neuropathic pain (DPNP)
- Postherpetic neuralgia (PHN)
- Peripheral neuropathic pain (PNP)
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✅ Description:
Mirogabalin, the active ingredient in Neumig, belongs to the class of gamma-amino acids and their derivatives. It selectively binds to the α2δ subunits of voltage-gated calcium channels (VGCCs). This action reduces calcium influx into the neuron, inhibiting neurotransmitter release and decreasing hyper-excitability in the central nervous system (CNS).
After oral administration, Mirogabalin is quickly absorbed, with the maximum plasma concentration reached within 0.5 to 1.5 hours. It has low plasma protein binding (about 25%) and is widely distributed in the body, with a volume of distribution ranging from 64 to 88 L. The drug is mainly excreted unchanged (61-72%) via the kidneys, with a small fraction (13-20%) metabolized by the liver. The elimination half-life is 2 to 4.9 hours.
Safety Advices
Alcohol
Mirogabalin can cause significant drowsiness, especially if combined with alcohol. Avoid alcohol during treatment
Pregnancy
CONSULT YOUR DOCTOR
There is insufficient information on the safety of Mirogabalin during pregnancy. Consult your doctor if you are pregnant or planning to conceive.
Breastfeeding
CONSULT YOUR DOCTOR
Information on the safety of Mirogabalin during breastfeeding is also limited. It is recommended to consult your doctor to weigh the benefits and risks.
Driving
Mirogabalin may cause sleepiness, dizziness, or vision issues. Avoid driving or operating heavy machinery if these effects occur.
Kidney
CONSULT YOUR DOCTOR
Mirogabalin should be used cautiously in patients with kidney disease. Dose adjustments may be necessary, so consult your doctor.
Liver
CONSULT YOUR DOCTOR
Mirogabalin is generally safe for patients with liver disease, and dose adjustment is not typically required.
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✔️ Dosage & Administration of Neumig 10
- Adults: The starting dose is 5 mg twice daily. The dose may be gradually increased by 5 mg every week, with a maximum dose of 15 mg twice daily. Adjustments can be made depending on the patient's age and symptoms, within the range of 10-15 mg twice daily.
- Children and Adolescents: Safety and effectiveness in children and adolescents have not been established.
- Hepatic Impairment: In patients with mild to moderate liver impairment, a single 15 mg dose of Mirogabalin is well tolerated. No data are available for severe liver impairment.
- Renal Impairment:
- Mild renal dysfunction: Start with 5 mg twice daily, gradually increasing to 10 mg twice daily.
- Moderate renal dysfunction: Start with 2.5 mg twice daily, gradually increasing to 7.5 mg twice daily.
- Severe renal dysfunction: Start with 2.5 mg once daily, gradually increasing to 7.5 mg once daily.
✔️ Side Effects of Neumig 10
Common side effects of Neumig include:
- Somnolence (drowsiness)
- Dizziness
- Edema (swelling)
- Weight gain
In rare cases, severe side effects may include:
- Dizziness, drowsiness, or loss of consciousness
- General malaise, loss of appetite, nausea, vomiting, jaundice (signs of liver dysfunction)
✔️ Interaction
- With Other Medications: Co-administration with cimetidine or probenecid may increase the plasma concentration of Neumig. If Neumig is taken with lorazepam, the sedative effects may be enhanced. Neumig is a substrate for several drug transporters, and co-administration with inhibitors of these transporters may increase drug exposure.
- With Food & Others: Taking Neumig with food does not significantly affect its absorption. However, avoid alcohol as it can enhance the sedative effects of Neumig and impair motor skills.
✔️ Mirogabalin is contraindicated in:
- Patients with a hypersensitivity to Mirogabalin
- Patients with mild to moderate hepatic and renal impairment
✔️ Pregnancy & Lactation
Mirogabalin should only be used during pregnancy if the benefits outweigh the risks. Animal studies have shown placental passage. It is also transferred into breast milk, so breastfeeding should be carefully considered by weighing the benefits and risks.
✔️ Precautions & Warnings
- Neumig may cause dizziness, drowsiness, or loss of consciousness. Patients should avoid operating heavy machinery or driving.
- Special care should be taken with elderly patients to avoid falls and fractures.
- Mirogabalin may cause blurred or double vision.
- If an allergic reaction occurs, discontinue the medication and consult a doctor.
- Dose adjustments are necessary for patients with renal dysfunction.
- Always consult a doctor before taking Neumig with other medications.
✔️ Storage Conditions
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
