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Axodin 180mg Tablet 1 Strip
Axodin is prescribed to alleviate symptoms of both seasonal and perennial allergic rhinitis in adults and children aged 12 years and above. It effectively relieves sneezing, runny nose, watery or itchy eyes, and itching of the nose, palate, or throat.
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✅ Description:
Histamine plays a key role in allergic responses by binding to H1 receptors, which triggers the release of inflammatory mediators such as interleukins, resulting in symptoms like itchiness, nasal discharge, and watery eyes.
Fexofenadine acts as an inverse agonist of the H1 receptor, stabilizing its inactive form and thereby preventing histamine-induced symptoms. It selectively targets peripheral H1 receptors without affecting dopaminergic, serotonergic, cholinergic, or adrenergic systems. Importantly, it does not cross the blood-brain barrier, minimizing the risk of sedation or CNS effects.
Symptoms may include dizziness, drowsiness, fatigue, and dry mouth. High doses (up to 800 mg) have not shown serious adverse effects in trials. Supportive care is recommended, as hemodialysis does not significantly eliminate the drug.
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✔️ Dosage & Administration
Allergic Rhinitis
Adults & children (12+ years):
- 60 mg twice daily, or
- 120 mg once daily, or
- 180 mg once daily
- Renal impairment: 60 mg once daily
Children (6–11 years):
- 30 mg twice daily, or
- 60 mg once daily
- Renal impairment: 30 mg once daily
Children (2–11 years):
- 30 mg (5 ml suspension) twice daily
- Renal impairment: 30 mg (5 ml) once daily
Chronic Idiopathic Urticaria
Adults & children (12+ years):
- 60 mg twice daily, or
- 120 mg once daily, or
- 180 mg once daily
- Renal impairment: 60 mg once daily
Children (6–11 years):
- 30 mg twice daily, or
- 60 mg once daily
- Renal impairment: 30 mg once daily
Children (6 months to <2 years):
- 15 mg (2.5 ml suspension) twice daily
- Renal impairment: 15 mg (2.5 ml) once daily
Children (2–11 years):
- 30 mg (5 ml suspension) twice daily
- Renal impairment: 30 mg (5 ml) once daily
- Renal impairment: Start with 60 mg once daily
- Hepatic impairment: No significant dose adjustment required
- Elderly: Generally well tolerated, but absorption may be increased
Use only under the guidance of a registered physician.
✔️ Side Effects
- Headache, drowsiness, dizziness
- Nausea
- Fatigue
- Allergic reactions (e.g., angioedema, dyspnea, anaphylaxis)
- Sleep disturbances, vivid dreams
- Fast or irregular heartbeat
- Rash, itching, urticaria
- Diarrhea
✔️ Drug Interactions
Fexofenadine is not metabolized by the liver, reducing potential drug interactions. Concurrent use with erythromycin or ketoconazole may elevate fexofenadine plasma levels 2–3 times without QT prolongation or additional side effects. No interaction with omeprazole was observed. However, antacids containing aluminum or magnesium may lower absorption; separate administration by at least 2 hours is recommended.
✔️ Contraindications
Not for use in individuals with known hypersensitivity to fexofenadine or any of its components.
✔️ Use in Pregnancy & Lactation
- Insufficient human data on safety during pregnancy. Use only if necessary.
- Fexofenadine may pass into breast milk, thus not recommended for nursing mothers.
✔️ Precautions
- Use with caution in elderly or renally impaired patients due to altered pharmacokinetics.
- Patients with cardiovascular conditions should be aware of possible tachycardia or palpitations associated with antihistamines.
- Axodin is unlikely to impair alertness or motor skills. However, individual response should be evaluated before operating machinery or driving.
✔️ Storage
Store in a dry, cool place, away from heat and direct light. Keep out of reach of children.
Disclaimer:
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
