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✅ Description:
Indications
Fexofenadine Hydrochloride is indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children. It is also indicated for the treatment of uncomplicated skin manifestations of chronic idiopathic urticaria.
Pharmacology
Fexofenadine Hydrochloride is an antihistamine with selective peripheral H1-receptor antagonist activity. It is rapidly absorbed after oral administration and peak plasma concentration is reached in 2-3 hours. It does not appear to cross the blood brain barrier.
Dosage & Administration
Seasonal Allergic Rhinitis-
Adults and children 12 years and older:
- Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
- In case of impaired renal function: 60 mg once daily
Children from 6 to 11 years:
- Tablet: 30 mg twice daily or 60 mg once daily
- In case of impaired renal function: 30 mg once daily
Children from 2 to 11 years
- Suspension: 30 mg or 5 ml twice daily
- In case of impaired renal function: 30 mg or 5 ml once daily.Chronic Idiopathic Urticaria-
Adults and children 12 years and older:- Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
- In case of impaired renal function: 60 mg once daily
- Tablet: 30 mg twice daily or 60 mg once daily
- In case of impaired renal function: 30 mg once daily
- Suspension: 15 mg or 2.5 ml (1/2 tsp) twice daily
- In case of impaired renal function: 15 mg or 2.5 ml (1/2 tsp) once daily
- Suspension: 30 mg or 5 ml (1 tsp) twice daily
- In case of impaired renal function: 30 mg or 5 ml (1 tsp) once daily
Interaction
Plasma concentration of Fexofenadine Hydrochloride have been increased when given with erythromycin or ketoconazole. Aluminium and magnesium hydroxide containing antacid reduces the absorption of Fexofenadine Hydrochloride.
Contraindications
Contraindicated in patients with known hypersensitivity to Fexofenadine Hydrochloride or any of its ingredients.
Side Effect
Common side effects are headache, fatigue, drowsiness, nausea, dry mouth and gastrointestinal disturbances.
Pregnancy & Lactation
US FDA pregnancy category of Fexofenadine Hydrochloride is C. So, Fexofenadine Hydrochloride should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.
Precautions & Warnings
Caution should be exercised in elderly patient and patient with decreased renal function.
Therapeutic Class
Non-sedating antihistamines
Storage Conditions
Store in a cold, dry, and light-protected location. Keep out of children's reach.
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