Epoetin 5000 IU Injection

✔️ Uses of Epoetin 5000 IU Injection

Anemia Associated with Chronic Renal Failure (CKD):

• For patients on dialysis and those not on dialysis.

Anemia in Non-Myeloid Malignancies Due to Chemotherapy:

• When anemia results from concomitant chemotherapy.

Anemic Patients Scheduled for Elective Surgery:

• To reduce the need for allogeneic blood transfusions.

Anemia Related to Zidovudine Therapy in HIV-Infected Patients:

• When zidovudine therapy induces anemia.

✔️ How does Epoetin 5000 IU Injection work?

Erythropoietin stimulates erythropoiesis by promoting the differentiation and proliferation of erythroid precursors, releasing reticulocytes, and synthesizing cellular hemoglobin.

✔️ Side Effects of Epoetin 5000 IU Injection

Common Side Effects:

• Nausea, vomiting, fever, and increased blood pressure are among the most commonly reported side effects.
• Flu-like symptoms such as headache, fatigue, dizziness, and body aches may also occur, especially at the beginning of treatment.
• If side effects persist, your doctor may suggest ways to manage or alleviate them.

Serious Side Effects:

• Inform your doctor immediately if you experience seizures (fits) or any other serious side effects.
• Epoetin 5000 IU Injection may rarely cause severe blood clots, requiring urgent medical attention.

✔️ Quick Suggestions:

• Erythropoietin is usually given in the clinical/hospital setting under the supervision of a qualified healthcare professional.
• Inform your doctor if you have an allergy to this medicine.
• Your doctor may suggest tests to monitor your kidney function while you are on treatment with this medicine.
• Report all your current medicines as well as your medical conditions to your doctor before receiving this medicine.

✔️ Indication of Epoetin 5000 IU Injection

Erythropoietin is a medicine that mimics the activity of Erythropoietin (a type of protein present in your body responsible for the production of red blood cells).

✔️ Pharmacology

• Epoetin 5000 IU Injection regulates erythropoiesis by stimulating the differentiation and proliferation of erythroid precursors.
• It stimulates the release of reticulocytes into circulation and the synthesis of cellular hemoglobin.
• Recombinant human Epoetin 5000 IU Injection, available as epoetin alfa and epoetin beta, is used in the management of anemias associated with CRF, cancer chemotherapy, and zidovudine therapy in HIV patients.

✔️ Dosage & Administration of Epoetin 5000 IU Injection

Adult Dose:

• Chronic Kidney Disease: Initially 50-100 units/kg IV/SC 3 times weekly.
• Zidovudine-Related Anemia: Initially 100 units/kg IV/SC 3 times weekly.
• Chemotherapy-Related Anemia: Initially 150 units/kg IV/SC 3 times weekly.
• Preparation for Surgery: Initially 300 units/kg SC once daily for 15 days.

Child Dose:

• Chronic Kidney Disease: Initially 50 units/kg IV/SC 3 times weekly.
• Zidovudine-Related Anemia: 50-400 units/kg SC/IV 2-3 times weekly.
• Chemotherapy-Related Anemia (5-18 years): Initially 600 units/kg IV once weekly.
• Epoetin 5000 IU Injection is administered via injection, either subcutaneously (under the skin) or intravenously (into a vein), as determined by your doctor.
• Typically, injections are given by a healthcare professional, such as a nurse or doctor.
• Dosage is determined based on body weight and the underlying cause of anemia.
• Iron supplements may enhance the effectiveness of this treatment.

✔️ Interaction of Epoetin 5000 IU Injection

It's crucial to be aware of potential interactions between medications and other substances. Here's some information on interactions involving Erythropoietin :

Interaction with Alcohol:

• The interaction with alcohol is unknown.
• It is advisable to consult your doctor before consumption.

Interaction with Other Medicines:

• Carfilzomib
• Thalidomide
• Lenalidomide
• Belzutifan

Disease Interactions:

• Information not available.

Food Interactions:

• Information not available.

Lab Interactions:

• Information not available.

✔️ Contraindications

• Uncontrolled Hypertension
• Hypersensitivity to Mammalian Cell Products or Human Albumin

✔️ Pregnancy & Lactation

• Pregnancy Category C. Use during pregnancy only if needed.
• Caution is advised during breastfeeding.

✔️ Precautions & Warnings:

• Before using Epoetin 5000 IU Injection, disclose to your doctor any history of uncontrolled high blood pressure, heart disease, or gout.
• Inform your doctor about all other medications you are taking, as they may interact with this treatment.
• Regular monitoring of blood pressure and other medical tests may be necessary to ensure the safety and effectiveness of the medication.
• Safety during pregnancy and breastfeeding has not been established; consult your doctor if you are pregnant, planning pregnancy, or breastfeeding.

✔️ Storage Conditions

Epoetin 5000 IU Injection should be stored in a refrigerator but used at room temperature.