Lonapam 0.5mg 10pcs

Indications of Lonapam 0.5 Tablet

It is prescribed to treat panic disorder, with or without agoraphobia. Panic disorder is defined by the occurrence of unexpected panic episodes and the related fear of experiencing further attacks, as well as anxiety about the implications or repercussions of the attacks.

It is also used alone or in combination to treat Lennox-Gastaut Syndrome (petit mal form), akinetic seizures, and myoclonic seizures. It may be used to treat individuals with absence seizures (petit mal) who have not responded to succinimides.

Clonazepam's efficacy in long-term usage, that is, for more than 9 weeks, has not been well investigated in controlled clinical studies. If a physician decides to use Clonazepam for a lengthy period of time, he or she should reassess the drug's long-term utility for the specific patient on a regular basis.

Pharmacology of Lonapam 0.5 Tablet

Clonazepam has benzodiazepine-like pharmacological characteristics, such as anticonvulsant, sedative, muscle relaxing, and anxiolytic actions. The central effects of benzodiazepines are mediated by an increase in GABAergic neurotransmission at inhibitory synapses. The affinity of the GABA receptor for the neurotransmitter is increased in the presence of benzodiazepines via positive allosteric regulation, resulting in a greater effect of released GABA on the postsynaptic transmembrane chloride ion flow.

There is additional evidence from animal studies that clonazepam has an influence on serotonin. Clonazepam rapidly suppresses many types of paroxysmal activity, including spike and wave discharge in the absence of seizures (petit mal), slow spike waves, generalized spike waves, spikes with temporal or other locations, and irregular spikes and waves, according to animal data and electroencephalographic studies in humans. Generalized EEG abnormalities are suppressed more frequently than localized abnormalities. Clonazepam appears to be helpful in both widespread and localized epilepsies, according to these studies.

Dosage & Administration of Lonapam 0.5 Tablet

Oral:

Adults: The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. The maximum recommended daily dose is 20 mg.

The initial dose for adults with panic disorder is 0.25 mg given in two divided doses. An increase to the target dose for most patients of 1 mg/day may be made after 3 days.

Pediatric Patients: In order to minimize drowsiness, the initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day but not exceed 0.05 mg/kg/day given in two or three divided doses.
Injection:

Infants and children: half of a vial (0.5 mg) by slow IV injection or by IV infusion.

Adults: 1 vial (1 mg) by slow IV injection or by IV infusion. This dose can be repeated as required (1-4 mg are usually sufficient to reverse the status). In adults, the rate of injection must not exceed 0.25 - 0.5 mg per minute (0.5-1.0 ml of the prepared solution) and a total dose of 10 mg should not be exceeded.

Interaction of Lonapam 0.5 Tablet

Clonazepam appears to have no effect on the pharmacokinetics of phenytoin, carbamazepine, or phenobarbital. Clonazepam's impact on the metabolism of other medications has not been studied.

Contraindications

It should not be taken in individuals who have a history of benzodiazepine hypersensitivity, or in patients who have clinical or biochemical indications of severe liver damage. It is safe to use in individuals with open-angle glaucoma who are getting adequate treatment, but it is not safe in people with acute narrow-angle glaucoma.

Side Effects of Lonapam 0.5 Tablet

Clonazepam's most common adverse effects are those associated with CNS depression. Drowsiness has been observed in around 50% of individuals treated for seizures, with ataxia occurring in approximately 30%. In some situations, symptoms may fade with time; behavioral issues have been reported in roughly 25% of patients. Aphonia, coma, tremors, vertigo, disorientation, depression, forgetfulness, hallucinations, hysteria, increased libido, sleeplessness, psychosis, and palpitations are all possible side effects.

Pregnancy & Lactation

Pregnancy: Based on preclinical research, it cannot be ruled out that clonazepam may cause congenital abnormalities. There is evidence from epidemiological studies that anticonvulsant medications are teratogens. However, it is impossible to establish which medication or combination of pharmaceuticals is to blame for birth abnormalities based on published epidemiological studies. Other variables, such as hereditary genetics or the epileptic disease itself, may be more important than medication therapy in causing birth abnormalities. Under these conditions, the medication should be given to pregnant women only if the potential benefits outweigh the danger to the fetus. Clonazepam should only be used during pregnancy if there is a compelling reason. High dosages administered in the latter trimester of pregnancy or during labor might induce abnormalities in the unborn child's heartbeat as well as hypothermia, hypotonia, moderate respiratory depression, and poor feeding in the neonate. It should be noted that both pregnancy and sudden withdrawal of medication might result in a worsening of epilepsy. Benzodiazepines have occasionally been linked to withdrawal symptoms in newborn babies.

Nursing Women: Although the active component in Clonazepam has been observed to transfer into breast milk in trace levels, mothers taking this medication should not nurse. If there is a strong need to use Clonazepam, breastfeeding should be stopped.

Precautions & Warnings

Clonazepam may increase the incidence or hasten the start of generalized tonic-clonic seizures when taken in individuals with multiple seizure disorders. This may necessitate the inclusion of anticonvulsants or an increase in their doses. Concurrent usage of valproic acid and Clonazepam may result in absent status.

Storage Conditions

Keep away from light and heat in a dry area. Keep out of children's reach.