Nexito 10mg 10pcs

Indications of Nexito 10 Tablet

Escitalopram Oxalate is indicated in the-

• Treatment of major depressive episodes.
• Treatment of panic disorder with or without agoraphobia.
• Treatment of social anxiety disorder (social phobia).
• Treatment of generalized anxiety disorder.
• Treatment of obsessive-compulsive disorder.

Pharmacology of Nexito 10 Tablet

Escitalopram is an oral selective serotonin reuptake inhibitor (SSRI). Escitalopram is the pure enantiomer of the racemic bicyclic phthalate derivative citalopram. By inhibiting 5HT reuptake, escitalopram is at least 100 times more effective than R enantiomer. Escitalopram has no or very low affinity for serotonergic or other receptors (including alpha and beta-adrenergic dopamine, histamine, muscarinic, and benzodiazepine receptors).

Dosage & Administration of Nexito 10 Tablet

The safety of daily doses above 20 mg has not been demonstrated. Escitalopram Oxalate is administered as a single daily dose and may be taken with or without food.

Major depressive episodes: Usual dosage is 10 mg once daily. Depending on individual patient response, the dose may be increased to a maximum of 20 mg daily. Usually, 2-4 weeks are necessary to obtain an antidepressant response. After the symptoms resolve, treatment for at least 6 months is required for consolidation of the response.

Panic disorder with or without agoraphobia: An initial dose of 5 mg is recommended for the first week before increasing the dose to 10 mg daily. The dose may be further increased, up to a maximum of 20 mg daily, dependent on individual patient response. Maximum effectiveness is reached after about 3 months. The treatment lasts several months.

Social anxiety disorder: Usual dosage is 10 mg once daily. Usually, 2-4 weeks are necessary to obtain symptom relief. The dose may subsequently, depending on individual patient response, be decreased to 5 mg or increased to a maximum of 20 mg daily. Social anxiety disorder is a disease with a chronic course, and treatment for 12 weeks is recommended to consolidate response. Long-term treatment of responders has been studied for 6 months and can be considered on an individual basis to prevent relapse; treatment benefits should be re-evaluated at regular intervals. Social anxiety disorder is a well-defined diagnostic terminology of a specific disorder, which should not be confounded with excessive shyness. Pharmacotherapy is only indicated if the disorder interferes significantly with professional and social activities. The place of this treatment compared to cognitive behavioral therapy has not been assessed. Pharmacotherapy is part of an overall therapeutic strategy.

Generalized anxiety disorder: Initial dosage is 10 mg once daily. Depending on the individual patient response, the dose may be increased to a maximum of 20 mg daily. Long-term treatment of responders has been studied for at least 6 months in patients receiving 20 mg/day. Treatment benefits and dose should be re-evaluated at regular intervals.

Obsessive-Compulsive Disorder: Initial dosage is 10 mg once daily. Depending on the individual patient response, the dose may be increased to a maximum of 20 mg daily. As OCD is a chronic disease, patients should be treated for a sufficient period to ensure that they are symptom-free. Treatment benefits and dose should be re-evaluated at regular intervals.

Interaction of Nexito 10 Tablet

Antidepressants such as SSRIs and related antidepressants should not be begun for at least two weeks after quitting an MAOI. An MAOI, on the other hand, should not be taken until at least one week after an SSRI or similar antidepressant has been discontinued (2 weeks in the case of paroxetine and sertraline, at least 5 weeks in the case of fluoxetine).

Contraindications

Patients who are known to be allergic to escitalopram or citalopram or any inactive ingredients of the drug should not use escitalopram. Concurrent use of escitalopram is prohibited in patients taking monoamine oxidase/pimozide.

Side Effects of Nexito 10 Tablet

Compared with tricyclic antidepressants, SSRIs have weaker sedative effects and less antimuscarinic and cardiotoxic effects. Side effects of SSRIs include gastrointestinal reactions (dose-related and fairly common including nausea, vomiting, indigestion, abdominal pain, diarrhea, and constipation), anorexia and weight loss (increase in appetite and weight gain), and allergic reactions, including Skin rash, urticaria, angioedema, allergic reactions, arthralgia, myalgia, and photosensitivity; other side effects include dry mouth, tension, anxiety, headache, insomnia, tremor, dizziness, fatigue, hallucinations, drowsiness, seizures, galactorrhea, Sexual dysfunction, urinary retention, sweating, hypomania or mania, dyskinesia and dyskinesia, visual impairment.

Pregnancy & Lactation

When using escitalopram to treat pregnant women in the third trimester, doctors must carefully consider the possible risks and benefits of the treatment. It is excreted in human breast milk. The decision to continue or stop breastfeeding or escitalopram treatment should take into account the risk of infant exposure to citalopram and the benefits of escitalopram treatment to the mother.

Precautions & Warnings

SSRIs should be used with caution in patients with epilepsy (avoid use when control is poor, stop if seizures occur), synchronized electroconvulsive therapy (fluoxetine reports prolonged seizures), history of mania, heart disease, diabetes, angle-closure glaucoma, Simultaneous use of Medicines increases the risk of bleeding, a history of bleeding disorders (especially gastrointestinal bleeding), liver and kidney damage.

Storage Conditions

Store below 30°C temperature and protect from light & moisture. Keep the medicine out of the reach of children.