Brodil HFA Inhaler Refill

 Indications

Brodil HFA Refill belongs to a class of drugs known as fast-acting bronchodilators or "relievers." It is used to treat asthma and chronic obstructive pulmonary disease (COPD) symptoms such as coughing, wheezing, and shortness of breath. Brodil HFA Refill can be taken with or without food. The dose will be determined by your condition and how you react to the medication. Take it at the same time every day if possible. It is critical that you continue to take this medication until your doctor instructs you.

Pharmacology

Salbutamol is a selective agonist of the 2-adrenoceptor. It works on the 2-adrenoceptors of bronchial smooth muscle at therapeutic levels but has little or no effect on the 1-adrenoceptors of cardiac muscle. In reversible airway blockage, salbutamol produces short-acting (4-6 hours) bronchodilation with a rapid onset (within 5 minutes). It also inhibits the release of bronchoconstrictor mediators such as histamine, neutrophil chemotactic factor (NCF), and prostaglandin D2 via acting as an anti-inflammatory on mast cells.

Dosage & Administration 

Administer Salbutamol Inhaler by oral inhalation only. Shake Salbutamol Inhaler well before each spray.
For relief of acute episodes of bronchospasm:

• Adults: 1 or 2 puffs as necessary. The maximum dose is up to 8 puffs in 24 hours.
• Children: Half the adult dose.

To prevent allergen-or exercise-induced bronchospasm:

• Adults: 2 puffs 15 minutes prior to exercise or exposure to the allergen. The maximum dose is 2 puffs, up to 4 times a day.
• Children: Half the adult dose.

Chronic therapy:

• Adults: Up to 200 mcg (2 puffs) four times daily.
• Children: Up to 200 mcg (2 puffs) four times daily.

Interaction

Salbutamol and non-selective beta-blockers like propranolol should not be prescribed simultaneously in most cases. 2-agonist treatment has the potential to cause significant hypokalemia. Concomitant treatment with xanthine derivatives, steroids, diuretics, and hypoxia may intensify this impact, therefore use caution if you have acute severe asthma. In such cases, it is advised that serum potassium levels be monitored.

Contraindications

Patients having a history of hypersensitivity to salbutamol or any other component of a Salbutamol inhaler should avoid using it.

Side Effects

Salbutamol is easily tolerated by most people. During inhalation, just a few adverse effects have been recorded. Tremors, anxiety, muscle cramps, headache, palpitation, a compensatory slight rise in heart rate, cardiac arrhythmias (including atrial fibrillation, supraventricular tachycardia, and extrasystoles), and tachycardia are all possible symptoms. Salbutamol inhalation can cause mouth and throat discomfort.

Pregnancy & Lactation

Pregnancy Classification C. In pregnant women, there are no sufficient and well-controlled studies using salbutamol inhalers or salbutamol sulfate. During pregnancy, this inhaler should only be used if the possible benefit outweighs the potential risk to the fetus. The components of the Salbutamol inhaler are not known to be excreted in human milk. When administering this inhaler to a nursing mother, exercise caution.

Precautions & Warnings

Paradoxical Bronchospasm: Inhaled salbutamol sulfate can cause life-threatening paradoxical bronchospasm. If paradoxical bronchospasm occurs, the Salbutamol inhaler should be stopped right away and another treatment plan implemented. When it comes to inhaled formulations, it's important to remember that paradoxical bronchospasm frequently develops after the first use of a new canister.

Storage Conditions

The canister has been pressurized. Even if the container appears to be empty, do not puncture, damage, or burn it. Keep out of direct sunshine and extreme heat. Keep it below 30°C. Do not allow yourself to become frozen. Keep your distance from the eyes. Keep your distance from youngsters. Only on or by a licensed physician's prescription will it be dispensed.