Trihale 100 Rotacap

✔️ Uses of Trihale 100 Rotacap

Treatment of Chronic obstructive pulmonary disease (COPD) and Asthma

✔️ How does Trihale 100 Rotacap work?

Fluticasone furoate reduces inflammation in the airways of the lungs. Thus, it helps to ease breathing problems in COPD and asthma patients. Umeclidinium and Vilanterol work together to help open and relax the muscles in the airways and make it easier for air to get in and out of the lungs.

✔️ Side Effects of Trihale 100 Rotacap

• Common cold
• Hoarseness
• Cough
• Headache
• Back pain
• Painful and frequent urination
• Itchy, runny, or blocked nose
• Sore, raised patches in the throat or mouth caused by a fungal infection

✔️ Directions for Use: Trihale 100 Rotacap

Before using, always check the label for instructions. Trihale 100 Rotacap is intended for oral inhalation only. Use it as directed by your doctor, following the prescribed dose and duration. Keep the inhaler closed until you're ready to use it. Shaking the inhaler is unnecessary and should be avoided. After inhaling, rinse your mouth with water and spit it out to help prevent fungal infections in the mouth and throat. Do not use more than once every 24 hours.

✔️ Pharmacology

This inhalation powder contains a combination of fluticasone furoate (a corticosteroid), umeclidinium (an anticholinergic), and vilanterol (a long-acting beta-agonist, or LABA). Vilanterol’s bronchodilatory effect is largely due to stimulation of adenyl cyclase, which increases cyclic AMP, relaxes bronchial muscles, and inhibits hypersensitivity mediators. Fluticasone furoate’s mechanism is not fully understood but reduces inflammation—a key factor in COPD and asthma—by acting on various cell types and mediators involved in inflammatory processes. Umeclidinium, a long-acting muscarinic antagonist, blocks M3 receptors in airway smooth muscle, leading to bronchodilation.

✔️ Dosage & Administration of Trihale 100 Rotacap

This capsule is for inhalation only and must not be swallowed. Open the capsule only immediately before use with the inhalation device. Rinse mouth with water after inhalation to lower the risk of oropharyngeal candidiasis.

• Adults (18+ years): Use at the same time daily, not more than once every 24 hours. For sudden breathing issues between doses, use an inhaled short-acting beta-agonist (SABA) for immediate relief.
  • COPD Maintenance: 1 inhalation capsule once daily.
  • Asthma Maintenance: 1 inhalation capsule once daily.

• Children & Adolescents: Not recommended; safety and efficacy in individuals under 18 are not established.
• Elderly: No dose adjustment is necessary, but sensitivity in some older patients may vary.
• Renal Impairment: Not studied.
• Hepatic Impairment: Not studied.

✔️ Interaction

• CYP3A4 inhibitors (e.g., ketoconazole): Use with caution; may cause systemic corticosteroid and cardiovascular effects.
• MAO inhibitors and tricyclic antidepressants: Use with caution; may enhance the vascular effects of vilanterol.
• Beta-blockers: Use with caution; they may interfere with bronchodilatory effects and cause severe bronchospasm.
• Diuretics: Use with caution, as beta-agonists may worsen ECG changes or hypokalemia associated with non–potassium-sparing diuretics.
• Anticholinergics: Avoid use with other anticholinergic drugs

✔️ Contraindications

• Not for primary treatment of status asthmaticus or acute COPD or asthma episodes.
• Contraindicated in patients with severe milk protein hypersensitivity or allergies to any ingredients.

✔️ Pregnancy & Lactation

Limited data on the use of this medication during pregnancy and lactation.

✔️ Precautions & Warnings

• LABA monotherapy can increase the risk of severe asthma-related events.
• Not for use in patients with acutely worsening COPD or asthma.
• Avoid combination with other LABA-containing medications to prevent overdose.
• Candida infections may occur in the mouth; advise patients to rinse their mouth after use.
• Increased pneumonia risk in COPD patients; monitor for symptoms.
• Discontinue if paradoxical bronchospasm occurs and switch to alternative therapy.
• Caution is advised in patients with cardiovascular disorders, urinary retention issues, and conditions like prostatic hyperplasia, bladder obstruction, convulsions, thyrotoxicosis, diabetes, and ketoacidosis.

✔️ Storage:

Store in a cool, dry place away from direct sunlight and heat. Keep out of reach of children and avoid contact with eyes.