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Dasanix 100mg Tablet 10pcs
Dasanix (Dasatinib), which is primarily used for the treatment of Philadelphia chromosome-positive (Ph+) leukemia.
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✅ Description:
Dasatinib works by inhibiting multiple kinases (e.g., BCR-ABL, SRC family kinases) and can overcome resistance to prior treatments like Imatinib. Key properties include:
- Absorption: Peaks in 0.5 to 6 hours.
- Distribution: Binds ~96% to plasma proteins.
- Metabolism: Primarily metabolized by CYP3A4.
- Excretion: Mostly via feces (~85%).
- Treatment of adult patients with:
- Newly diagnosed Ph+ CML in the chronic phase.
- Advanced phases of CML or Ph+ ALL with resistance or intolerance to prior therapy.
- Treatment of pediatric patients (1 year and older) with:
- Chronic phase Ph+ CML.
- Newly diagnosed Ph+ ALL (in combination with chemotherapy).
✔️ Uses
- Blood cancer (Chronic myeloid leukemia)
✔️ How does
Dasatinib works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
✔️ Dosage and Administration
Adults:
- Chronic phase CML: 100 mg orally once daily.
- Advanced phases of CML/Ph+ ALL: 140 mg orally once daily.
- Tablets must be swallowed whole, not crushed or cut.
Pediatrics:
- Dosage is based on body weight, ranging from 40 mg to 100 mg daily.
- Regular recalculation of doses based on weight changes is necessary.
✔️ Common adverse reactions include:
- Myelosuppression
- Bleeding events
- Fluid retention
- Pulmonary arterial hypertension
- QT prolongation
- Severe dermatologic reactions
✔️ Interactions
- CYP3A4 inhibitors/inducers: May increase or decrease Dasanix levels, affecting efficacy and toxicity.
- Gastric acid-reducing agents: Avoid proton pump inhibitors and H2 antagonists; use antacids instead with proper timing.
✔️ Pregnancy and Lactation
- Contraindicated in pregnancy due to potential fetal harm.
- Breastfeeding is not recommended during and up to 2 weeks after the last dose.
✔️ Precautions and Warnings
- Myelosuppression: Requires frequent blood count monitoring.
- Fluid retention and cardiovascular events: Monitor and manage as needed.
- Pulmonary arterial hypertension (PAH): Evaluate for cardiopulmonary issues before and during treatment.
- QT prolongation: Monitor patients with risk factors.
- Severe dermatologic reactions: Discontinue if severe mucocutaneous reactions occur.
- Tumor lysis syndrome: Ensure proper hydration and monitoring in high-risk patients.
✔️ Storage
- Store below 30°C in a dry, light-protected place.
- Keep out of reach of children.
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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