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Folinex 15mg Tablet
Folinic Acid (Calcium folinate)
- Colorectal Cancer: Used as an adjunct to fluorouracil for chemotherapy treatment.
- Methotrexate Toxicity: Acts as an antidote for the toxicity caused by methotrexate.
- Folate-Deficient Megaloblastic Anaemia: To treat folate deficiency-related anemia.
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✅ Description:
Folinic acid (calcium folinate) enters cells as 5-methyl tetrahydrofolate, providing the necessary cofactor that is blocked by methotrexate.
- It stabilizes the binding of 5-dUMP to thymidylate synthetase and enhances the activity of fluorouracil.
- It neutralizes the toxic effects of methotrexate while increasing the efficacy of fluorouracil.
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✔️ Dosage & Administration
For Adults:
Oral Antidote for Methotrexate Toxicity:
- 15 mg every 6 hours for 10 doses, starting 24 hours after methotrexate infusion.
- Continue until serum methotrexate levels are <0.05 micromolar.
- Can be administered via IM/IV injection as an alternative.
For Folate-Deficient Megaloblastic Anaemia:
- 15 mg daily (oral route).
Adjunct to Fluorouracil in Colorectal Cancer:
- 200 mg/m² Body Surface Area (BSA) via slow IV injection over at least 3 minutes, followed by 370 mg/m² fluorouracil by IV injection.
- Treatment is given for 5 consecutive days and repeated every 28 days for 2 courses.
- Subsequent doses may be repeated every 4-5 weeks if the patient has recovered from the toxic effects.
Intramuscular Folate-Deficient Megaloblastic Anaemia:
- Up to 1 mg/day.
Always follow a healthcare professional’s advice for accurate dosing.
✔️ Side Effects
Common:
- Allergic reactions (e.g., rash, pruritus, erythema, urticaria).
- Nausea, vomiting, fever.
Serious:
- Rare side effects like severe enterocolitis, diarrhea, and dehydration (especially in elderly patients).
✔️ Drug Interactions
- Fluorouracil: Folinic acid may increase toxicity when given with fluorouracil.
- Sulfamethoxazole-Trimethoprim: Folinic acid can reduce its efficacy in treating pneumocystis carinii pneumonia.
- Other Interactions: Be cautious when combined with other medications such as methotrexate, warfarin, anticonvulsants, and antibiotics.
✔️ Contraindications
- Hypersensitivity to folinic acid or any component of the product.
- Pernicious anemia or any other megaloblastic anemia caused by vitamin B12 deficiency.
- Intrathecal or intraventricular administration.
✔️ Precautions
- Undiagnosed Megaloblastic Anaemia: Ensure diagnosis of megaloblastic anemia before use.
- Folate-Dependent Tumors: Exercise caution.
- Pregnancy: Use only if the potential benefit justifies the risk to the fetus.
- Monitor Serum Methotrexate Levels: Essential for determining optimal dose and duration.
- Monitor Electrolytes and Liver Function: Regular testing is advised.
✔️ Storage Conditions
- Store below 30°C.
- Keep away from light and moisture.
- Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
