Geficent 250mg Tablet 10pcs

✔️ Uses of Geficent

• Used to manage adults with non-small cell lung cancer

✔️ How does Geficent work?

Geficent works by decreasing the survival rate and proliferation of cancer cells in lung tissues by blocking a protein called epidermal growth factor receptor (EGFR) which is responsible for the growth and spread of cancer cells thereby controlling the growth and spread of cancer cells to other parts of the body.

✔️ Side Effects of Geficent

Common side effects include:

• Interstitial Lung Disease (ILD)
• Hepatotoxicity (elevated ALT, AST, or bilirubin)
• Gastrointestinal perforation
• Severe or persistent diarrhea
• Ocular disorders (keratitis, dry eye, blepharitis)
• Bullous and exfoliative skin disorders (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome)

✔️ Quick Suggestions:

• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Get adequate sleep as resting helps in improving your health, and mental ability and improves attention.
• De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
• Do not take antacids (to reduce the acid level of your stomach) 2 hours before or 1 hour after taking this medicine.
• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
• Foods containing fiber help in better digestion. These include beans, peas, lentils, whole grains,  nuts, and seeds.
• Avoid smoking and alcohol consumption.

✔️ Dosage & Administration of Geficent

Recommended Dose:
250 mg orally once daily, with or without food, until disease progression or unacceptable toxicity occurs.

Missed Dose:
If a dose is missed, do not take it within 12 hours of the next scheduled dose.

Patients with Swallowing Difficulties:

• Immerse the tablet in 4–8 ounces of water.
• Stir for approximately 15 minutes.
• Drink the liquid immediately or administer it through a nasogastric tube.
• Rinse the container with 4–8 ounces of water and drink the rinse or administer it via the nasogastric tube.

Pediatric Use:
Safety and effectiveness in children have not been established.

Renal Impairment:
No studies were conducted in patients with severe renal impairment.

Hepatic Impairment:
Use with caution, and monitor for adverse effects.

✔️ Interaction

CYP3A4 Inducers:
Strong inducers (e.g., rifampicin, phenytoin) increase the metabolism of Geficent, reducing its effectiveness. The dose may be increased to 500 mg daily and reduced back to 250 mg 7 days after discontinuing the inducer.

CYP3A4 Inhibitors:
Strong inhibitors (e.g., ketoconazole) increase plasma concentrations of Geficent.

✔️ Contraindications:

Known hypersensitivity to Gefitinib or any component of the drug.

✔️ Pregnancy & Lactation

Pregnancy:

• Geficent may harm the fetus. Pregnant women should avoid its use, and women of childbearing potential must use effective contraception during treatment and for 6 months after the last dose.
• Male patients with female partners should use contraception during treatment and for 3 months after the last dose.

Lactation:

• It is unknown whether Geficent is excreted in human milk. Breastfeeding is not recommended during treatment or for 2 weeks after the last dose.

✔️ Precautions & Warnings

Interstitial Lung Disease (ILD):

• Occurs in 1.3% of patients.
• Discontinue if ILD is confirmed.

Hepatotoxicity:

• Monitor liver function periodically.
• Discontinue in cases of severe hepatic impairment.

Gastrointestinal Perforation:

• Rare but serious (0.1%). Discontinue treatment immediately if it occurs.

Severe Diarrhea:

• Withhold treatment for Grade 3 or 4 diarrhea lasting more than 14 days.

Ocular Disorders:

• Monitor for keratitis, corneal erosion, or aberrant eyelash growth.
• Discontinue in severe cases.

Bullous and Exfoliative Skin Disorders:

• Rare but serious. Discontinue treatment if these conditions develop.

✔️ Storage:

• Store at 20°–25°C in a cool, dry place, away from sunlight.
• Keep out of reach of children.