✔ 100% Authentic Product
Palbokin 125mg Capsule 7pcs
Palbociclib inhibits Cyclin-dependent kinases (CDK) 4 and 6, which are key regulators of cellular proliferation. It works by:
- Blocking the transition from the G1 phase to the S phase in the cell cycle reduces the proliferation of estrogen receptor (ER)-positive breast cancer cells.
- Decreasing retinoblastoma (RB) protein phosphorylation, leads to reduced E2F signaling and enhanced cell growth arrest when combined with antiestrogens.
- Inducing sustained cell senescence when used alongside antiestrogens, greater effects were observed when antiestrogen treatment continued after Palbokin discontinuation.
- Demonstrating stronger tumor growth inhibition in combination with letrozole compared to either drug alone in patient-derived ER-positive breast cancer models.
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
Cashback offer (Optional):
🔹 Foreign manufacturer products are not applicable for Cashback offer
Cash on Delivery - All over Bangladesh
Urgent Delivery - 2 Hours Dhaka City
ফ্রি ডেলিভারি! - ১৪৯৯ টাকা+ অর্ডারে ঢাকা
শহরে ।- ফ্রি ডেলিভারি! - ২৯৯৯ টাকা+ অর্ডারে ঢাকার
বাহিরে ।
✅ Description:
Palbokin is a kinase inhibitor used to treat hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. It is prescribed in combination with:
- An aromatase inhibitor was the first endocrine-based therapy for postmenopausal women.
- Fulvestrant for women whose disease has progressed after prior endocrine therapy.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses of Palbokin 125
- Treatment of Breast cancer
✔️ How does Palbokin 125 work?
Palbociclib selectively and reversibly inhibits cyclin-dependent kinases (CDK) 4 and 6. These kinases, along with cyclin D1, play a role in cell proliferation by regulating the cell cycle progression from the G1 to S phase. Inhibiting CDK4/6 slows the proliferation of breast cancer cells.
✔️ Common Side Effects: Palbokin 125
- Decreased white blood cell (WBC) and neutrophil counts
- Neutropenia, thrombocytopenia, and anemia
- Nausea, vomiting, diarrhea, and fatigue
- Hair loss, rash, and dry skin
- Mouth and lip inflammation
- Increased AST and ALT levels
✔️ Serious Side Effects: Palbokin 125
- Neutropenia: Occurs in up to 80% of patients, with febrile neutropenia reported in 1.8%. Regular blood monitoring is essential.
- Interstitial Lung Disease (ILD)/Pneumonitis: Severe or life-threatening cases have been observed. Patients should report symptoms like cough or shortness of breath immediately.
- Embryo-Fetal Toxicity: Can harm a developing fetus. Women of reproductive age should use effective contraception during treatment and for 3 weeks after stopping Palbokin.
✔️ Dosage & Administration of Palbokin 125
- Recommended Dose: 125 mg capsule, taken orally once daily for 21 consecutive days, followed by a 7-day break (28-day cycle).
- Administration Instructions:
- Take with food at the same time each day.
- For men undergoing Palbokin with an aromatase inhibitor, treatment with an LHRH agonist may be considered based on clinical guidelines.
- Dose Adjustments for Adverse Reactions:
- Starting Dose: 125 mg/day.
- First Reduction: 100 mg/day.
- Second Reduction: 75 mg/day.
- Discontinue treatment if further dose reduction is required.
Note: Not approved for use in children.
✔️ Renal Dose Adjustments: Palbokin 125
- Mild, moderate, or severe renal impairment (CrCl >15 mL/min): No dose adjustment required.
- Hemodialysis: Not studied.
✔️ Drug Interactions: Palbokin 125
Agents That Increase Palbokin Plasma Levels:
- Strong CYP3A inhibitors (e.g., Itraconazole, Ketoconazole, Ritonavir) can increase Palbokin levels by 87%.
- Avoid concomitant use or reduce Palbokin dosage.
- Avoid grapefruit or grapefruit juice.
Agents That Decrease Palbokin Plasma Levels:
- Strong CYP3A inducers (e.g., Rifampin, Carbamazepine, Phenytoin) can reduce Palbokin levels by 85%.
- Avoid concomitant use.
Drugs Affected by Palbokin:
- Palbokin increases the plasma concentration of CYP3A substrates (e.g., Midazolam, Fentanyl, Tacrolimus).
- Dose adjustments of these drugs may be necessary.
✔️ Pregnancy & Lactation
- Palbokin can harm a fetus if administered during pregnancy. Pregnant women should be advised of this risk.
- The drug’s excretion in breast milk is unknown. Use during breastfeeding should be avoided unless necessary.
✔️ Warnings & Precautions
- Neutropenia: Monitor blood counts before treatment, at the start of each cycle, and during the second cycle. Adjust the dose or delay treatment if severe neutropenia occurs.
- ILD/Pneumonitis: Interrupt treatment immediately if symptoms develop, and discontinue permanently for severe cases.
- Contraception: Women should use effective birth control during treatment and for 3 weeks post-treatment.
✔️ Storage:
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
