Pansec-IV 40 Injection

Indications

Pantoprazole is demonstrated where concealment of corrosive emission has helpful advantage; i.e 

Peptic ulcer diseases

Gastroesophageal reflux diseases

Ulcer initiated by non-steroidal anti-inflammatory drugs (NSAIDs)

Eradication of Helicobacter pylori (in combination with antibiotics)

Zollinger-Ellison Disorder

Pharmacology

Pantoprazole may be a proton pump inhibitor that stifles the ultimate step in gastric corrosive generation by covalently official to the H+/K+ATPase protein framework at the surface of the gastric parietal cell. This impact leads to restraint of both basal and invigorated gastric corrosive discharge, independent of the jolt that endures longer than 24 hours.

Dosage & Administration

Oral: 

Benign gastric ulcer: 40 mg day by day within the morning for 4 weeks, proceeded for assist 4 weeks, on the off chance that not completely healed.

Gastro-esophageal reflux disease: 20-40 mg every day within the morning for 4 weeks, proceeded for assist 4 weeks, in case not completely mended; upkeep measurements is 20 mg every day, which may be expanded to 40 mg daily.

Duodenal ulcer: 40 mg day by day within the morning for 2 weeks, proceeded for assist 2 weeks in case not completely recuperated.

Duodenal ulcer related with Helicobacter pylori: Pantoprazole is suggested at a measurements of 40 mg twice day by day in affiliation with antimicrobial specialists as point by point underneath: Amoxycillin 1 g and Clarithromycin 500 mg both twice day by day for one week, or Clarithromycin 250 mg and Metronidazole 400 mg both twice every day for one week.

Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg day by day for those require long-term NSAID treatment.

Zollinger-Ellison Disorder: At first 80 mg once every day balanced concurring to reaction (elderly max. 40 mg day by day); every day dosages over 80 mg given in 2 isolated doses.

IV Injection: 

Duodenal ulcer and gastric ulcer: 40 mg once day by day for 7-10 days

Gastroesophageal reflux illness related with a history of erosive esophagitis: 40 mg once every day for 7-10 days Prevention of rebleeding in peptic ulcer: IV 80 mg, taken after by 8 mg/hour mixture for 72 hours

Prophylaxis of corrosive yearning: 80 mg IV each 12 h for 24 h, taken after by 40mg each 12 hour

Long-term administration of Zollinger-Ellison Disorder and other obsessive hypersecretory conditions: 80 mg IV each 12 hours, may increment to 80 mg each 8 hours in the event that required, may titrate to higher dosages depending on corrosive yield.

Interaction

No critical medicate intelligent have been watched in clinical ponders.

Contraindications

Pantoprazole is contraindicated in patients with known extreme touchiness to any of the components of the detailing.

Side Effects

Pantoprazole is well endured in both short-term and long-term treatment. Cerebral pain and the runs are the common side impacts and seldom included side impacts are stomach,torment, tooting, hasty, sleep deprivation and hyperglycemia.

Pregnancy & Lactation

US FDA Pregnancy Category of Pantoprazole is B. There are, be that as it may,no satisfactory and well-controlled thinks about in pregnant lady. Since creature generation ponders are not  continuously prescient of human reaction, this sedate ought amid pregnancy as it were on the off chance that clearly required. Pantoprazole has been appeared to be excreted in human drain. So, a choice ought to be made whether to cease nursing or to suspend the medicate, taking into consideration the advantage of the medicate to the  mother.

Precautions & Warnings

Patients ought to be cautioned that Pantoprazole tablet ought to not be part, chewed or pulverized. Long-term treatment of Pantoprazole may lead to malabsorption of  cyanocobalamin (Vitamin B12) or may increment the hazard of osteoporosis related clutters.

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry put, absent from light and warm. Keep out of the reach of children.