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Renvista is the first orally administered HIF-PH inhibitor designed to stimulate erythropoiesis by increasing the body's natural production of erythropoietin. It also enhances iron regulation and reduces the effects of inflammation that suppress hemoglobin synthesis and red blood cell production by downregulating hepcidin.
Renvista belongs to the class of drugs used for hemolytic, hypoplastic, and renal anemia. Renvista is prescribed for the treatment of symptomatic anemia in adult patients associated with chronic kidney disease (CKD).
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✅ Description:
Roxadustat, the active ingredient in Renvista, is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) with anti-anemic properties. By inhibiting HIF-PH, an enzyme that degrades hypoxia-inducible factors (HIFs) under normal oxygen levels, it prevents HIF breakdown and enhances HIF activity. This results in increased production of endogenous erythropoietin, promoting red blood cell production and improving iron metabolism. Roxadustat also lowers hepcidin levels, ensuring better iron availability and hemoglobin synthesis, even in inflammatory conditions.
Roxadustat has been shown to enhance red blood cell production while keeping plasma erythropoietin levels within a near-normal physiological range. It helps improve iron absorption, transport, and hemoglobin synthesis, while also significantly reducing cholesterol levels, regardless of whether lipid-lowering agents are used.
✔️ Uses of Renvista 70
- Gastroesophageal reflux disease (Acid reflux)
- Peptic ulcer disease
- Heartburn
✔️ Dosage & Administration of Renvista 70
- Frequency: Taken orally three times a week on non-consecutive days.
- Dosage for non-ESA-treated patients:
- Adults: Initial dose of 50 mg three times weekly.
- For patients under 100 kg: 70 mg three times weekly.
- For patients over 100 kg: 100 mg three times weekly.
- Dosage for patients switching from ESA therapy:
- Adults: 70-100 mg three times weekly.
- Adjust the dosage based on the patient’s hemoglobin (Hb) response.
Dose Adjustment:
Increase or decrease doses as required to maintain target Hb levels (10-12 g/dL). Adjustments must follow the dose adjustment sequence, with a minimum 4-week interval before making further changes.
Overdose
- Symptoms: May lead to transient increases in heart rate or excessively high hemoglobin levels.
- Management: Reduce or interrupt the dosage as needed. Note that Renvista is not removed via dialysis.
Missed Dose:
- If more than 24 hours remain before the next scheduled dose, take the missed dose immediately and continue as scheduled.
- If less than 24 hours remain, skip the missed dose and proceed with the next scheduled dose. Do not take two doses on the same day.
Tablets can be taken with or without food.
- Children: Not recommended for pediatric use.
- Liver dysfunction: Not advised for severe hepatic impairment.
✔️ How does Renvista 70 work?
Renvista 70 works by reducing the acid produced in the stomach which helps in the relief of acid-related indigestion and heartburn.
✔️ Side Effects of Renvista 70
Common side effects include hypertension, vascular access thrombosis, diarrhea, peripheral edema, hyperkalemia, and nausea.
✔️ Quick Suggestions:
- If prescribed once daily, take Roxatidine before bedtime. It is particularly effective at controlling stomach acid released during sleep.
- If you are using additional acidity medications (e.g., antacids), take them either 2 hours before or 2 hours after Roxatidine.
- Avoid soft drinks and citrus fruits like oranges and lemons, as they may irritate the stomach and trigger increased acid secretion.
- Inform your doctor if symptoms persist after 2 weeks of Roxatidine use, as it could indicate another underlying condition.
- Notify your doctor if you have a history of kidney disease, as your dosage may need adjustment.
- Do not stop using Roxatidine without consulting your doctor.
- Roxatidine is generally well-tolerated and has a low risk of side effects.
✔️ Indication of Renvista 70
Roxatidine is used in the treatment of gastroesophageal reflux disease and peptic ulcer disease.
✔️ Interaction
With phosphate binders or multivalent cation-containing products (except lanthanum carbonate):
- Risk: Decreased Renvista absorption.
- Recommendation: Take Renvista at least 1 hour after these medications.
With gemfibrozil or probenecid:
- Risk: Increased Renvista exposure.
- Recommendation: Adjust dosage based on hemoglobin monitoring.
With OATP1B1 or BCRP substrates (e.g., simvastatin, rosuvastatin):
- Risk: Increased drug exposure.
- Recommendation: Adjust dosage as necessary.
✔️ Contraindications:
Hypersensitivity
✔️ Pregnancy & Lactation
- Pregnancy: Not recommended for use during pregnancy.
- Breastfeeding: Contraindicated for nursing mothers.
✔️ Precautions & Warnings
- Use cautiously in patients with a history of thrombotic vascular events, obesity, or seizures.
- Do not use in patients with active infections or severe liver disorders.
- Not suitable for pregnant women.
✔️ Storage:
Store below 30°C in a dry, cool place, away from light and moisture. Keep out of reach of children.
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