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Lopirel Plus (30pcs Box)
Clopidogrel 75mg + Aspirin 75mg-
Acute Coronary Syndrome (ACS):
- Reduces the risk of Myocardial Infarction (MI) and Stroke in patients with:
- Non-ST-segment elevation ACS (Unstable Angina/NSTEMI).
- Acute ST-segment elevation ACS (STEMI).
Recent MI, Stroke, or Peripheral Arterial Disease:
- Reduces the risk of MI and Stroke in patients with a history of:
- Recent Myocardial Infarction (MI).
- Recent Stroke.
- Established Peripheral Arterial Disease.
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✅ Description:
Clopidogrel:
- A prodrug that inhibits platelet activation and aggregation.
- Irreversibly binds to the P2Y12 ADP receptor on platelets, preventing clot formation.
- Begins to inhibit platelet aggregation within 2 hours of administration.
- Steady-state inhibition is reached between Day 3 and Day 7.
Aspirin:
- Irreversibly inhibits cyclooxygenase (COX-1), preventing the production of thromboxane A2.
- Thromboxane A2 is responsible for platelet aggregation and vasoconstriction.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects: Lopirel Plus
Common:
- Increased bleeding risk.
- Bruising.
- Gastrointestinal discomfort.
Rare but Serious:
- Thrombotic Thrombocytopenic Purpura (TTP): Blood disorder causing clotting issues.
- Reye’s Syndrome: Risk in children with viral infections (flu, chickenpox).
✔️ Pharmacokinetics:
Absorption:
- Clopidogrel is rapidly absorbed with at least 50% bioavailability.
- Aspirin is well absorbed and reaches peak plasma levels within 30-40 minutes.
Metabolism & Elimination:
- Clopidogrel is metabolized primarily in the liver.
- 50% is excreted in urine, and 46% in feces within 5 days.
- Aspirin is hydrolyzed into salicylic acid and excreted by the kidneys.
✔️ Dosage & Administration: Lopirel Plus
- Standard Dose: Clopidogrel 75 mg once daily with or without food.
- Acute Coronary Syndrome:
- Loading dose: 300 mg Clopidogrel (one-time).
- Maintenance dose: 75 mg Clopidogrel daily + Aspirin (75-325 mg) daily.
✔️ Drug Interactions: Lopirel Plus
- Aspirin: Enhances the effect of Clopidogrel but increases the risk of bleeding.
- Heparin: No dose adjustment needed, but increased bleeding risk.
- NSAIDs: Increased risk of gastrointestinal bleeding.
- Warfarin: Increased risk of bleeding. Co-administration should be done with caution.
✔️ Contraindications:
- Hypersensitivity to Clopidogrel, Aspirin, or any component.
- Active bleeding disorders (e.g., Peptic Ulcer, Intracranial Hemorrhage).
✔️ Overdose Management: Lopirel Plus
Clopidogrel Overdose:
- Risk of severe bleeding – platelet transfusion may be required.
Aspirin Overdose:
- Symptoms: Dizziness, headache, tinnitus, confusion, nausea.
- Severe cases: Respiratory/metabolic acidosis, hyperthermia, dehydration.
- Treatment: Activated charcoal, gastric lavage, and hemodialysis if necessary.
✔️ Pregnancy & Lactation:
Pregnancy:
- 1st & 2nd trimesters: Use only if needed.
- 3rd trimester: Contraindicated due to bleeding risk.
Lactation:
- Clopidogrel: Unknown if excreted in human milk.
- Aspirin: Known to be excreted in breast milk – not recommended during breastfeeding.
✔️ Precautions & Warnings:
- May prolong bleeding time – use cautiously in patients with a bleeding risk.
- Monitor for signs of bleeding (black stools, unusual bruising).
- Avoid use in children <12 years due to the risk of Reye’s Syndrome.
✔️ Storage Conditions:
- Store below 30°C, in a cool & dry place, protected from light & moisture.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
