Lipicon 20mg 10pcs

Indications of Lipicon 20

Atorvastatin is demonstrated as an aide to eat less to decrease hoisted add up to cholesterol, LDL cholesterol, apolipoprotein B (Apo-B) and triglycerides levels in taking after infections when the reaction to slim down and other non-pharmacological measures is inadequate. To decrease add up to cholesterol and LDL cholesterol in patients with heterozygous and homozygous familial hypercholesterolaemia. To decrease raised cholesterol and triglycerides in understanding with blended dyslipidemia (Fredrickson Sort Ia and Ib). For the treatment of patients with raised serum triglyceride levels in hypertriglyceridaemia (Fredrickson Sort IV). For the treatment of patients with dysbetalipoproteinaemia (Fredrickson Sort III). To decrease cardiac ischaemic occasions in patients with asymptomatic or mellow to direct symptomatic coronary supply route illness with raised LDL-cholesterol level. To diminish add up to and LDL-cholesterol concentrations patients with hypercholesterolemia related with or exacerbated by diabetes mellitus.

Pharmacology of Lipicon 20

Atorvastatin may be a particular inhibitor of HMG-CoA reductase. This protein is the rate-limiting protein mindful for the transformation of HMG-CoA to mevalonate, a forerunner of sterols, counting cholesterol. Atorvastatin brings down plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol amalgamation within the liver and increments the number of hepatic LDL receptors on the cell surface for upgraded take-up and catabolism of LDL.

Administration & Dosage

Primary hypercholesterolaemia and combined hyperlipidaemia-
 

Adults: Usually 10 mg once daily; if necessary, may be increased at intervals of at least 4 weeks to the max. 80 mg once daily.

Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to the usual max. 20 mg once daily.

Familial hypercholesterolaemia-
 

Adults: Initially 10 mg daily, increased at intervals of at least 4 weeks to 40 mg once daily; if necessary, further increased to max. 80 mg once daily (or 40 mg once daily combined with anion-exchange resin in heterozygous familial hypercholesterolaemia).

Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to the usual max. 80 mg once daily.

Prevention of cardiovascular events-
 

Adults: Initially 10 mg once daily adjusted according to the response.

Interaction of Lipicon 20

The chance of myopathy amid treatment with Lipicon 20 is expanded with the concurrent organization of cyclosporin, fibric corrosive subordinates, erythromycin, azole antifungals and niacin. No clinically noteworthy intuitive were seen when Atorvastatin was managed with antihypertensives or hypoglycemic specialists. Patients ought to be closely checked on the off chance that Atorvastatin is included to digoxin, erythromycin, verbal contraceptives, colestipol, stomach settling agent and warfarin.

Contraindications

Patients who are hypersensitive to any component of Lipicon 20 should avoid taking it. Active liver disease or unexplained persistent transaminase elevations are contraindicated with atorvastatin. It's also not recommended for patients who have had a serious reaction to HMG-CoA reductase inhibitors in the past.

Side Effect of Lipicon 20

The chance of myopathy amid treatment with Lipicon 20 is expanded with the concurrent organization of cyclosporin, fibric corrosive subordinates, erythromycin, azole antifungals and niacin. No clinically noteworthy intuitive were seen when Atorvastatin was managed with antihypertensives or hypoglycemic specialists. Patients ought to be closely checked on the off chance that Atorvastatin is included to digoxin, erythromycin, verbal contraceptives, colestipol, stomach settling agent and warfarin.

Pregnancy & Lactation

Lipicon 20 is generally well-tolerated. The most frequent side effects related to Atorvastatin are constipation, flatulence, dyspepsia, abdominal pain. Other side effects include infection, headache, back pain, rash, asthenia, arthralgia, myalgia.

Precautions & Warnings

In patients with epilepsy (avoid if poorly controlled, discontinue if convulsions develop), concurrent electroconvulsive therapy (prolonged seizures reported with fluoxetine), history of mania, cardiac disease, diabetes mellitus, angle-closure glaucoma, concomitant use of drugs that increase bleeding risk, and history of bleeding disorders, SSRIs should be used with caution.

Therapeutic Class

Statins and other anti-anginal and anti-ischaemic drugs

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.