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✅ Description:
Indications
Heterozygous Hypercholesterolemia is treated with rosuvastatin (Familial and Non familial)
Hypercholesterolemia Homozygous (Familial)
Dyslipidemia (Mixed) (Fredrickson Type IIa and IIb)
Primary cardiovascular disease prevention
Pharmacology
Rosuvastatin could be a specific and competitive inhibitor of HMG-CoA reductase, the rate-limiting protein that changes over 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a antecedent of cholesterol. Rosuvastatin produces its lipid-modifying impacts in two ways. To begin with, it increments the number of hepatic LDL receptors on the cell surface to upgrade take-up and catabolism of LDL. Moment, Rosuvastatin inhibits hepatic blend of VLDL, which diminishes the whole number of VLDL and LDL particles.
Administration & Dosage
Dose range: 5-40 mg once daily. Use 40 mg dose only for patients not reaching LDL-C goal with 20 mg
HoFH: Starting dose 20 mg/day.
Pediatric patients with HeFH: 5-10 mg/day for patients 8 to less than 10 years age, and 5-20 mg/day for patients 10 to 17 years of age.
Pediatric patients with HoFH: 20 mg/day for patients 7 to 17 years of age.
Interaction
Surprising sedate intelligent of Rosuvastatin are- Cyclosporine: Combination increments Rosuvastatin presentation. Rosuvastatin measurements ought to be constrained to 5 mg once daily. Gemfibrosil: Combination ought to be dodged. On the off chance that utilized together, Rosuvastatin measurements ought to be restricted to 10 mg once daily. Lopinavir/Ritonavir or atazanavir/ritonavir: Combination increments Rosuvastatin introduction. Rosuvastatin measurements ought to be to 10 mg once daily. Coumarin anticoagulants: Combination draws out worldwide normalized proportion (INR). Steady INR ought to be accomplished earlier to beginning Rosuvastatin. INR ought to be observed habitually until steady upon start or modification of Rosuvastatin therapy. Concomitant lipid-lowering treatments: Utilize with fibrates and niacin items may increment the chance of skeletal muscle impacts.
Contraindications
If you have a known hypersensitivity to any of the product's ingredients, you should avoid taking rosuvastatin.
Unexplained persistent elevations in hepatic transaminase levels are a sign of liver disease.
Women who are pregnant or may become pregnant
Mothers who are breastfeeding
Side Effect
Rosuvastatin is well tolerated by most people. Headache, myalgia, constipation, asthenia, abdominal pain, and nausea were the most common side effects linked to Rosuvastatin.
Pregnancy & Lactation
The safety of the drug in pregnant women has yet to be determined. Rosuvastatin is not known whether or not it is excreted in human milk.
Precautions & Warnings
Skeletal muscle impacts (e.g., myopathy and rhabdomyolysis): Dangers increment with utilize of 40 mg measurements, progressed age (>65 years), hypothyroidism, renal impedance, and combination utilize with cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir or certain other lipid-lowering drugs. Patients ought to be exhorted to instantly report unexplained muscle torment, delicacy, or shortcoming. Rosuvastatin can be ceased on the off chance that signs or side effects appear. Liver chemical anomalies and checking: Diligent rises in hepatic transaminases can occur.
Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.
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