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Thyrox 12.5mcg Hypothyroidism Tablet
- Continue taking even if you feel better—this is usually a lifelong therapy.
- Inform your doctor if you become pregnant, change medications, or experience symptoms of hyperthyroidism.
- If you miss a dose, take it as soon as you remember. If it's nearly time for the next dose, skip the missed dose—do not double up.
- Do not use Thyrox 12.5 as a weight loss aid in euthyroid individuals.
- Monitor Regular thyroid function tests (TSH, T4)
- Monitor heart rate, blood pressure, and clinical signs of over- or under-replacement
- Adjust dose based on weight changes and lab results
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✅ Description:
Thyrox 12.5 is a synthetic thyroid hormone replacement used in the treatment of hypothyroidism, a condition where the thyroid gland fails to produce adequate thyroid hormone. Restoring normal hormone levels helps regulate energy, metabolism, and overall body function.
Thyrox 12.5 contains levothyroxine sodium, a synthetic form of the natural thyroid hormone T4. It increases basal metabolic rate (BMR), promotes protein synthesis, and stimulates metabolism of carbohydrates, fats, and vitamins. Its activity is largely mediated through conversion to triiodothyronine (T3) at the cellular level, influencing growth, development, and metabolic regulation.
Your healthcare provider will determine the appropriate starting dose based on your thyroid hormone levels, assessed via blood tests. Once therapy begins, periodic monitoring is essential to ensure optimal dose adjustment and therapeutic effectiveness.
Adult Dosing
Mild Hypothyroidism: 1.7 mcg/kg/day; usual initial dose: 25–50 mcg/day.
Age >50 or with cardiovascular disease: Start at 12.5–25 mcg/day; titrate every 4–8 weeks.
Severe Hypothyroidism: Begin with 12.5–25 mcg/day; increase by 25 mcg/day every 2–4 weeks as needed.
Pediatric Dosing
Neonates & Infants (1–12 months): 6–15 mcg/kg/day.
Children (1–12 years): 4–6 mcg/kg/day.
Adolescents (>12 years): 2–3 mcg/kg/day or up to 150 mcg/day.
- Dosing should be individualized based on body weight, age, and disease severity.
- Untreated thyrotoxicosis (hyperthyroidism)
- Uncorrected adrenal insufficiency
- Recent myocardial infarction (MI)
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses
- Primary Hypothyroidism
- TSH Suppression in Thyroid Cancer or Nodular Disease
- Myxedema Coma (as adjunctive therapy)
✔️ Dosage & Administration
- Take orally once daily, preferably in the morning on an empty stomach (30–60 minutes before food), with a full glass of water.
- Do not chew or crush the tablet.
- Avoid food, milk, tea, or supplements (especially calcium, iron, or antacids) for at least 1 hour before and 2 hours after taking the tablet.
✔️ Common Side Effects
Side effects often result from excessive dosing and may include:
- Palpitations, tachycardia, flushing
- Nervousness, anxiety, restlessness, insomnia
- Weight loss, diarrhea, vomiting, headache
- Muscle weakness, heat intolerance
✔️ Severe Adverse Effects
- Thyrotoxic crisis (rare but potentially fatal): hyperthermia, convulsions, arrhythmias, heart failure, coma
- Osteopenia/osteoporosis due to increased bone turnover, especially in postmenopausal women
✔️ Drug Interactions
- Reduced absorption with: calcium carbonate, iron supplements, antacids, cholestyramine, sucralfate
- Reduced efficacy with: rifampin, phenytoin, carbamazepine, phenobarbital, lithium, estrogens
- Altered thyroid levels with: amiodarone, propranolol, sertraline
- May increase anticoagulant effects of warfarin
- May alter insulin or antidiabetic drug requirements
- Enhanced cardiovascular effects when used with sympathomimetics (e.g., epinephrine)
- Maintain a 4-hour gap between Thyrox and any interfering agents.
✔️ Use with caution in:
- Cardiovascular disease, such as heart failure, angina, or hypertension
- Diabetes mellitus and diabetes insipidus
- Epilepsy, long-standing hypothyroidism, or myasthenic disorders
- Elderly patients
- Pregnancy and lactation: Dose adjustments may be necessary during pregnancy
✔️ Storage:
Keep in a dry place away from light and heat. Keep out of the reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
