Tetrazin 12.5mg Tablet 10pcs

✔️ Uses of Tetrazin 12.5mg Tablet

Huntington's Disease

✔️ Side Effects of Tetrazin 12.5mg Tablet

• Major adverse responses include depression and suicidality.
• Other side effects include akathisia, restlessness, agitation, dysphagia, parkinsonism, somnolence, and sedation.

✔️ How does Tetrazin 12.5mg Tablet work?

Tetrazin 12.5mg Tablet works by inhibiting the absorption of certain chemicals (dopamine, serotonin) in the brain which results in improved movements thus treating hyperkinetic motor disorders associated with Huntington's chorea in affected individuals.

✔️ Quick Suggestions:

• Avoid activities requiring mental focus as Tetrabenazine may cause drowsiness.
• May be taken with or without food.
• Do not stop taking it without consulting your doctor to prevent worsening symptoms.
• Not recommended for children under 18 years old.
• Inform your doctor about all current medications and medical conditions.
• Consult your doctor if pregnant or breastfeeding before taking Tetrabenazine.

✔️ Indication of Tetrazin 12.5mg Tablet

Tetrabenazine is used to treat the chorea associated with Huntington's disease.

✔️ Pharmacology:

• At dosages of 50 mg, Tetrabenazine can prolong the QTc interval.
• Tetrabenazine or its metabolites bind to melanin-containing tissues in rats, such as the eyes and skin.
• Tetrabenazine is a reversible inhibitor of human vesicular monoamine transporter type 2, depleting reserves of monoamine neurotransmitters like serotonin, norepinephrine, and dopamine.

✔️ Dosage & Administration of Tetrazin 12.5mg Tablet

• Dosage is individualized based on the patient's response and tolerance.
• Initial dose: 12.5 mg per day, gradually titrated up to 50 mg per day.
• Dosing recommendations above 50 mg per day require testing for metabolizer status.

✔️ Interaction

Before taking Tetrazin 12.5mg Tablet, it's crucial to inform your doctor if you are currently taking any of the following medications:

1. Reserpine: Used to control high blood pressure and treat psychosis.
2. Antidepressants: Including MAO inhibitors such as phenelzine and selegiline.
3. Levodopa: Utilized in the treatment of Parkinson’s disease.
4. Opioids: Pain control medications like oxycodone and hydrocodone.
5. Antihypertensive drugs: Used to treat high blood pressure, such as telmisartan and chlorthalidone.
6. Beta-blockers: Medications for heart problems like acebutolol and atenolol.
7. Medications for psychotic disorders: Including hypnotics like Ambien and Belsomra, and neuroleptics like butaperazine.
8. CYP2D6 inhibitors: Medicines that reduce the metabolism of certain drugs, such as fluoxetine, paroxetine, terbinafine, moclobemide, and quinidine.
9. Medications that prolong the QTc interval in the ECG: Examples include haloperidol and droperidol.
10. Certain antibiotics: Used to treat bacterial infections, such as gatifloxacin and moxifloxacin.
11. Medications used to treat heart rhythm conditions: Such as quinidine, procainamide, amiodarone, and sotalol.

✔️ Contraindications:

• Not recommended for patients who are actively suicidal or have untreated or inadequately treated depression.
• Contraindicated in patients with hepatic impairment or taking MAOIs.

✔️ Pregnancy & Lactation

• Pregnancy Category C; should only be used if the potential benefit outweighs the risk to the fetus.
• Not known to be excreted in human milk; the decision to breastfeed or stop breastfeeding should consider the drug's importance to the mother.

✔️ Precautions & Warnings

• May worsen parkinsonism symptoms; caution is advised when driving or performing specialized duties.
• Use with caution during pregnancy.

✔️ Storage Conditions

• Keep Tetrazin 12.5mg Tablet out of reach of children
• Store Tetrazin 12.5mg Tablet at room temperature