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Angilock Plus 50/12.5mg Tablet 1 Strip
Angilock Plus tablet is used to treat hypertension (high blood pressure). It also helps reduce the risk of stroke in patients with high blood pressure and left ventricular hypertrophy (enlarged heart muscle).
Losartan, an Angiotensin II receptor blocker (ARB), blocks the actions of Angiotensin II, a substance that constricts blood vessels and increases blood pressure. By blocking Angiotensin II from binding to its receptor (AT1), Losartan helps relax blood vessels, lowering blood pressure. It also reduces aldosterone secretion, which decreases sodium and water retention.
Hydrochlorothiazide, a thiazide diuretic, works by increasing urine output, reducing the volume of fluid in the blood vessels, and lowering blood pressure. It also causes the loss of sodium, chloride, and potassium through urine.
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✅ Description:
Angilock Plus 50/12.5 is used to treat hypertension (high blood pressure) and reduce the risk of stroke in patients with high blood pressure. It is typically prescribed when a single medication is not sufficient to control blood pressure. Hypertension is a chronic condition that increases the risk of heart diseases, such as heart attack and stroke.
- Losartan (angiotensin II receptor antagonist): It helps relax and widen the blood vessels, improving blood flow and lowering blood pressure.
- Hydrochlorothiazide (thiazide diuretic): Prevents the reabsorption of excess salt and reduces fluid retention in the body, which also helps in lowering blood pressure.
- Angilock Plus 50/12.5 can be taken with or without food. Swallow the tablet whole with a glass of water.
- The doctor will guide you on the appropriate dosage based on your medical condition.
- Do not use these unless advised by your doctor, as they may affect potassium levels.
- In rare cases, Angilock Plus 50/12.5 can cause muscle pain, dark urine, tenderness, or weakness. Seek medical help immediately if you notice these symptoms.
- Angilock Plus 50/12.5 should not be used during pregnancy or if you plan to get pregnant. Discontinue use and consult your doctor if you become pregnant while taking it.
- Do not use Angilock Plus 50/12.5 if you are unable to urinate.
- Do not take Angilock Plus 50/12.5 with medications containing aliskiren, as it can interact unfavorably.
Safety Advices
Alcohol
UNSAFE
Alcohol should not be consumed with Angilock Plus 50/12.5 tablet as it may cause orthostatic hypotension (a type of low blood pressure that occurs when you stand up after sitting down or lying).
Pregnancy
UNSAFE
Angilock Plus 50/12.5 is not recommended for use during the first 3 months of pregnancy. This medicine should not be used in women who are more than 3 months pregnant. Inform your doctor if you are pregnant or planning on becoming pregnant before starting this medicine. Also, if you become pregnant while taking this medicine, talk to your doctor immediately.
Breastfeeding
UNSAFE
Angilock Plus 50/12.5 is not recommended during breastfeeding. Inform your doctor if you are breastfeeding before starting this medicine.
Driving
CAUTION
Angilock Plus 50/12.5 may cause dizziness or drowsiness. If you experience any such effects after taking this medicine that may affect your ability to drive safely, it is advised to avoid driving.
Kidney
Angilock Plus 50/12.5 is not recommended for use in patients with severe kidney impairment or kidneys not producing any urine. It should be used with caution in patients having renal artery stenosis (narrowing of renal arteries) or functioning of one kidney or having had a recent kidney transplant. Consult your doctor before taking Angilock Plus 50/12.5
Liver
Angilock Plus 50/12.5 is not recommended for use in patients with severe liver impairment. It should be used with caution in patients having a history of mild to moderate liver impairment. Consult your doctor before taking Angilock Plus 50/12.5
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✔️ Some side effects may include:
- Common side effects: Upper respiratory infections, dizziness, tiredness, nausea, diarrhea, back pain, and cold/flu symptoms like cough.
- These side effects usually resolve on their own but consult your doctor if they persist.
✔️ Medical Conditions to Inform Your Doctor About:
- Liver disease
- Kidney failure
- Glaucoma (high eye pressure)
- Electrolyte imbalances (e.g., high or low magnesium or potassium levels)
- Allergies or asthma
- Lupus (autoimmune disease)
- Diabetes
✔️ Dosage of Angilock Plus 50/12.5
- Hypertension: The usual starting dose is one tablet of 50/12.5 mg once daily. If one tablet doesn't provide adequate blood pressure control, the dose can be increased to 100/25 mg once daily.
- Left Ventricular Hypertrophy: Start with 50/12.5 mg daily, then increase the dose to 100/12.5 mg and 100/25 mg if additional blood pressure reduction is needed.
- Severe Hypertension: Begin with 50/12.5 mg once daily, then increase to 100/25 mg daily if needed.
- The maximum dose is 100/25 mg once daily.
- Renal Impairment: Safe for patients with creatinine clearance >30 ml/min.
- Hepatic Impairment: Avoid titration in patients with liver dysfunction due to the inability to give a 25 mg dose of Losartan.
- Pediatrics: Safety and effectiveness in children have not been established.
✔️ Directions for Use:
Angilock Plus can be taken with or without food and may be combined with other antihypertensive medications.
✔️ Interaction
- Losartan: No significant interactions with Hydrochlorothiazide, Digoxin, Warfarin, Cimetidine, and Phenobarbital. However, combining with potassium-sparing diuretics, potassium supplements, or salt substitutes may increase potassium levels.
- Hydrochlorothiazide: May interact with alcohol, barbiturates, narcotics, and antidiabetic drugs. It may enhance the effects of other antihypertensive agents and reduce the absorption of Hydrochlorothiazide when combined with cholestyramine or colestipol resins.
✔️ Contraindications
This medication is contraindicated for patients with a hypersensitivity to any component of the product, those with anuria, or a hypersensitivity to sulfonamide-derived drugs.
✔️ Overdose Effects
- Losartan: Overdose symptoms may include hypotension and tachycardia. If symptomatic hypotension occurs, supportive care should be provided.
- Hydrochlorothiazide: Overdose may cause electrolyte imbalances (hypokalemia, hypochloremia) and dehydration.
✔️ Pregnancy & Lactation
- Pregnancy: ARBs like Losartan should be avoided during pregnancy, especially in the second and third trimesters, as they may cause harm to the fetus.
- Breastfeeding: Not recommended for breastfeeding women.
✔️ Precautions & Warnings
- Electrolyte imbalances (e.g., hypokalemia) may occur, especially with diuretic therapy.
- Renal and liver impairment may require dose adjustments or alternative medications.
- Skin protection is advised due to an increased risk of skin cancer with long-term use.
✔️ Storage:
Store below 30°C and keep out of reach of children.
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