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Generic Name: Bisoprolol + Amlodipine Company Name: Opsonin Pharma Limited
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✅ Description:
Indication
For the treatment of hypertension in patients whose blood pressure is adequately controlled by the individual medications given concurrently at the same dose levels as in the combination, but as separate tablets, the bisoprolol & amlodipine combination is recommended.
Pharmacology
Bisoprolol hemifumarate is the ß1 blocker that is the most selective. Of all the beta-blockers on the market right now, it has the highest affinity for the ß1 receptor. lowers heart rate, cardiac output, and arterial blood pressure by blocking the ß1 adrenergic receptor in the heart and vascular smooth muscle. ß-blockers can affect lipid metabolism in patients taking non-ß1 selective ß1-blockers, but long-term use of Bisoprolol does not result in any changes to the cholesterol fraction, including the heart-protective HDL cholesterol.
Dosage & Administration
Adult Dose
Oral Adult 1 tablet once daily
Interactions
Other ß-blocking medications should not be taken with bisoprolol.
Contraindications
Right ventricular failure secondary to pulmonary hypertension and sinus bradycardia in individuals with cardiogenic shock, overt heart failure, second or third-degree A-V block, and sinus bradycardia.
Side-Effects
- Sleepiness
- Headache
- Ankle swelling
- Flushing (sense of warmth in the face, ears, neck, and trunk)
- Slow heart rate
- Tiredness
- Palpitations
- Nausea
- Edema (swelling)
- Constipation
- Cold extremities
Pregnancy
Bisoprolol's safety during pregnancy has yet to be determined.
Precautions
During long-term bisoprolol medication, renal, hepatic, and hematologic functions should be monitored at regular intervals.
Storage Conditions
Keep away from light and heat in a dry location. Keep out of children's reach.
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