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Cefixime is a semisynthetic third-generation cephalosporin that kills bacteria by disrupting the synthesis of their cell walls. It is stable against beta-lactamase enzymes, which makes it effective against resistant bacteria. Its absorption is approximately 40%-50%, irrespective of food intake.
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✅ Description:
Afix (Cefixime) is a third-generation cephalosporin antibiotic with bactericidal activity against a wide range of Gram-positive and Gram-negative bacteria. It is used to treat the following infections caused by susceptible microorganisms:
Upper Respiratory Tract Infections (URTI):
- Includes conditions like otitis media or other URTI, especially when resistant bacteria or significant treatment failure risks are suspected.
Lower Respiratory Tract Infections (LRTI):
- Includes bronchitis.
Urinary Tract Infections (UTI):
- Includes conditions like cystitis, cystourethritis, and pyelonephritis.
Pathogens Treated:
- Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella species, Haemophilus influenzae (beta-lactamase positive/negative), Moraxella catarrhalis (beta-lactamase positive/negative), and Enterobacter species.
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✔️ Afix 200: Side Effects
Gastrointestinal:
- Diarrhea, stool changes (more common with higher doses), nausea, abdominal pain, dyspepsia, vomiting, flatulence, and rarely pseudomembranous colitis.
Central Nervous System:
- Headache and dizziness.
Hypersensitivity Reactions:
- Rash, pruritus, urticaria, drug fever, arthralgia (typically resolves upon discontinuation).
Hematological:
- Rare cases of thrombocytopenia, leukopenia, and eosinophilia.
Miscellaneous:
- Genital pruritus and vaginitis.
✔️ Dosage and Administration of Afix 200
- Treatment duration: Typically 7 days but may extend up to 14 days if necessary.
- Food: Absorption is not significantly affected by food.
Dosage:
- Adults and Children Over 10 Years: 200–400 mg daily as a single dose or divided into two doses, depending on the severity of the infection.
- Elderly: Same as adult dosage. Dosage adjustments may be necessary for severe renal impairment.
- Children (6 months–10 years): 8 mg/kg/day as a single or divided dose. Suggested daily suspension doses:
- 6 months to 1 year: 3.75 mL
- 1–4 years: 5 mL
- 5–10 years: 10 mL
- Typhoid Fever: 5 mg/kg body weight twice daily for 10–14 days.
- Children Over 50 kg or Older than 10 Years: Use adult dosage.
- Children Under 6 Months: Safety and efficacy not established.
Renal Impairment:
- If creatinine clearance is ≥20 mL/min: Normal dose.
- If creatinine clearance <20 mL/min: Do not exceed 200 mg once daily.
✔️ Drug Interactions
- Gastric lavage may be considered. No specific antidote is available.
- Cefixime is not significantly removed by hemodialysis or peritoneal dialysis.
✔️ Drug Interactions
- Cephalosporins, including Cefixime, may prolong prothrombin time. Caution is advised in patients on anticoagulants.
✔️ Contraindications
- Known hypersensitivity to cephalosporins or any component of the medication.
✔️ Use in Pregnancy and Lactation
- Pregnancy: No adequate studies are available. Should only be used if needed.
- Lactation: It is unknown if Cefixime is excreted in human milk. Use with caution in nursing mothers.
✔️ Precautions and Warnings
Allergy Risk:
- Exercise caution in patients with penicillin allergies, as cross-reactivity between penicillins and cephalosporins is possible.
- Discontinue immediately if an allergic reaction occurs.
Renal Impairment:
- Monitor renal function closely and adjust dosage as necessary.
Antibiotic-Associated Diarrhea:
- Broad-spectrum antibiotics may disrupt normal gut flora, potentially leading to Clostridium difficile-associated diarrhea.
✔️ Storage Conditions
- Store below 30°C, protected from light and moisture.
- Keep out of reach of children.
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