Itrostred OC Cream 15g

✔️ Uses of Itrostred OC Cream 15gm

This cream is used for:

• Treating inflamed fungal skin infections such as tinea corporis, tinea cruris, and tinea pedis
• Managing mixed bacterial and fungal infections of the skin
• Treating secondary infected dermatoses with inflammation
• Controlling infected eczematous dermatitis and atopic dermatitis

✔️ How Itrostred OC Cream 15gm Works

Itrostred OC Cream combines four active ingredients that work together to treat skin infections:

• Clobetasol propionate (0.05%) – A potent corticosteroid that reduces inflammation by inhibiting the release of inflammatory substances in the body.
• Itraconazole (1%) – A broad-spectrum antifungal that disrupts fungal cell membrane synthesis by blocking ergosterol production, ultimately stopping fungal growth.
• Ofloxacin (0.75%) – A fluoroquinolone antibiotic that prevents bacterial DNA replication by inhibiting essential bacterial enzymes (DNA gyrase and topoisomerase IV), thereby stopping bacterial growth.
• Ornidazole (2%) – An antibacterial and antiprotozoal agent that damages the DNA of susceptible microorganisms, leading to their destruction.

✔️ Common side effects of Itrostred OC Cream may include:

• Mild reactions – Burning sensation, redness, irritation, rash, itching, dryness, or flaking of the skin.
• Allergic contact dermatitis – A skin reaction causing redness, itching, and possible blisters.
• Hormonal effects – Hypothalamic-pituitary-adrenal (HPA) axis suppression, leading to fatigue, nausea, and appetite loss.
• Cushing’s syndrome – A hormonal imbalance that may cause rapid weight gain in the face and upper body.
• Hyperglycemia – Elevated blood sugar levels.
• Opportunistic skin infections – Infections occurring in individuals with weakened immune systems.

✔️ To use Itrostred OC Cream effectively:

1. Ensure your skin is clean and dry before application.
2. Apply a thin layer of the cream to the affected area twice daily (morning and evening).
3. Gently massage until fully absorbed.
4. Wash your hands thoroughly after use to prevent the spread of infection.
5. Follow your doctor’s instructions for best results.

✔️ Managing Side Effects

Most side effects are mild and resolve when the treatment is discontinued. However, if symptoms persist or worsen, consult a doctor.

• For a burning sensation – Applying the cream before bedtime may help.
• For irritation or redness – Applying in the morning allows you to monitor skin reactions during the day.

✔️ To enhance recovery and prevent reinfection while using Itrostred OC Cream:

• Practice good hygiene – Wash your hands and the affected area with mild soap to reduce the risk of irritation and secondary infections.
• Avoid scratching or rubbing – This can worsen inflammation and slow healing.
• Wear loose, breathable clothing – Cotton and other natural fibers allow the skin to breathe and help prevent irritation.

✔️ Daily Dose

Use Itrostred OC Cream exactly as prescribed by your doctor. Dosage may vary depending on your condition and how well you respond to treatment. Avoid exceeding the recommended dose without consulting your doctor.

✔️ Overdose

Applying too much cream may cause skin irritation or redness. If this happens, rinse the area with cool water. If irritation persists, seek medical advice.

✔️ Missed Dose

If you forget a dose, apply it as soon as you remember. However, if it's close to the time for your next application, skip the missed dose and continue as usual. Do not apply extra cream to make up for a missed dose.

✔️ Interactions of Itrostred OC Cream 15gm

Drug-Drug Interactions

Itrostred OC Cream may interact with the following medications:

• Oral Anticoagulants – Clobetasol can enhance the effects of blood thinners like warfarin and heparin, increasing the risk of bleeding.
• Non-Depolarizing Muscle Relaxants – Clobetasol may intensify the effects of muscle relaxants such as atracurium and rocuronium.
• CYP3A4-Metabolized Drugs – Itraconazole is a strong CYP3A4 inhibitor, which may elevate the levels of medications like simvastatin (a statin) and amiodarone (an antiarrhythmic drug).
• Drugs That Prolong QT Interval – Ofloxacin may interact with drugs like erythromycin and ketoconazole, potentially increasing the risk of heart rhythm disturbances.

Drug-Food Interactions

Since Itrostred OC Cream is applied topically, there are no known food interactions, and diet does not influence its effectiveness.

Drug-Disease Interactions

• Allergic Reactions – Individuals with hypersensitivity to any of the cream’s ingredients (clobetasol, itraconazole, ofloxacin, ornidazole) should avoid using it.
• Viral Infections – The steroid component (clobetasol) may worsen conditions like herpes simplex, vaccinia, and varicella (chickenpox).

✔️ To preserve the effectiveness of Itrostred OC Cream, follow these storage guidelines:

• Store below 25°C and do not freeze.
• Keep the tube tightly closed to prevent air exposure.
• Avoid direct sunlight and humid environments.
• Keep out of reach of children.
• Do not use expired cream.
• Avoid contact with the eyes—if accidental contact occurs, rinse with water immediately.