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Generics: Almotriptan 6.25mg
Nipro JMI Pharma Ltd
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✅ Description:
Indications of Altrip
Altrip is used to treat the acute headache phase of migraine attacks with or without aura. Almotriptan is the only oral triptan approved in the United States for the treatment of migraine headaches in adolescents 12 to 17 years of age.
Pharmacology
Almotriptan is a potent and selective serotonin agonist (serotonin 1B / 1D). Almotriptan binds to specific serotonin receptors in meningeal arteries, inhibits the release of vasoactive peptides and causes arteries to contract. It has limited effect on the arteries that supply blood to the brain, and has little effect on the heart and lung vessels.
Dosage & Administration of Altrip
Acute Treatment of Migraine Attacks: The recommended dose of Almotriptan in adults and adolescents age 12 to 17 years is 6.25 mg to 12.5 mg, with the 12.5 mg dose tending to be a more effective dose in adults. If the headache is relieved after the initial almotriptan malate dose but returns, the dose may be repeated after 2 hours. The maximum daily dose should not exceed 25 mg. The safety of treating an average of more than four migraines in a 30-day period has not been established.
Hepatic Impairment: The recommended starting dose of almotriptan malate in patients with hepatic impairment is 6.25 mg. The maximum daily dose should not exceed 12.5 mg over a 24-hour period
Renal Impairment: The recommended starting dose of almotriptan malate in patients with severe renal impairment is 6.25 mg. The maximum daily dose should not exceed 12.5 mg over a 24-hour period
Interactions
According to reports, these drugs cause long-term vasospasm. During the combined use of triptans and selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SSRIs), life-threatening cases of serotonin syndrome have been reported .
Contraindications
Like other 5HT1B / 1D receptor agonists, almotriptan should not be used in patients with a history, symptoms or signs of ischemic heart disease (myocardial infarction, angina pectoris, documented asymptomatic ischemia, Prinzmetal's angina) or severe and mild hypertension or moderate uncontrolled. High blood pressure Combination with ergotamine, ergotamine derivatives (including mexiergot) and other 5HT1B / 1D agonists is prohibited.
Side Effects of Altrip
Severe cardiac reactions including myocardial infarction have occurred after using Almotriptan malate tablets. These reactions are extremely rare and most have been reported in patients with predictive risk factors for CAD (coronary artery disease).
Pregnancy
Pregnancy category C. There are no data on the excretion of almotriptan in human milk.
Precautions
Allergy to active ingredients or any excipient. Patients with severe liver damage, previous cerebrovascular accident (CVA), transient ischemic attack (TIA), and peripheral vascular disease.
Storage Conditions
Keep below 30° C temperature in a dry place. Protected from light. Do not freeze. Keep out of the reach of children.
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