Enurex Oral Solution 60ml Bottle

Enurex Solution contains desmopressin, a synthetic analogue of the natural antidiuretic hormone vasopressin, which plays a key role in regulating the body’s water balance. It works by increasing water reabsorption in the kidneys, thereby reducing excessive urine output and controlling abnormal thirst in patients with diabetes insipidus.

Enurex Solution is also effective in decreasing night-time urine production, making it useful in the management of nocturnal enuresis (bedwetting) and nocturia. Additionally, it has haemostatic properties, as it stimulates the release of clotting factors, helping to reduce bleeding episodes in conditions such as Hemophilia A, Von Willebrand Disease (Type 1), and uremic bleeding associated with acute or chronic renal failure.

Adult Dosage

Diabetes Insipidus

Intranasal:

10–40 mcg once daily, administered as a single dose or divided into 2–3 doses

Usual dose: 20 mcg daily in 2 divided doses

Morning and evening doses should be adjusted to maintain normal daily water balance

Oral:

Initial: 0.05 mg every 12 hours

Effective range: 0.1–1.2 mg/day in divided doses every 8–12 hours

Fluid intake restriction is essential

IV/SC:

2–4 mcg/day in divided doses every 12 hours

Approximately one-tenth of the intranasal maintenance dose

Hemophilia A

IV:

0.3 mcg/kg administered over 15–30 minutes

For surgical procedures, give 30 minutes prior

Intranasal:

<50 kg: 150 mcg

≥50 kg: 300 mcg

For preoperative use, administer 2 hours before the procedure

Von Willebrand Disease (Type 1)

IV:

0.3 mcg/kg over 15–30 minutes

Preoperative dose: 30 minutes before surgery

Intranasal:

<50 kg: 150 mcg

≥50 kg: 300 mcg

Administer 2 hours prior to procedure

Nocturnal Enuresis

Oral: 0.2 mg at bedtime

May be increased up to 0.6 mg/day if required

Nocturia (Adults)

Preservative-free nasal spray:

Ages 50–<65 years: 1.66 mcg nightly, 30 minutes before bedtime

≥65 years: 0.83 mcg nightly; dose may be increased after 7 days if serum sodium remains normal

Sublingual tablets:

Women: 27.7 mcg once daily, 1 hour before bedtime

Men: 55.3 mcg once daily, 1 hour before bedtime

Administer without water and only if serum sodium is normal

Uremic Bleeding

0.4 mcg/kg IV over 10 minutes

Pediatric Dosage

Diabetes Insipidus

3 months–12 years: 5–30 mcg intranasally once daily, as a single dose or divided

>12 years: 10–40 mcg once daily in divided doses

Dosage should be individualized to maintain appropriate diurnal water balance

Nocturnal Enuresis

Children >6 years: 0.2 mg orally at bedtime (maximum 0.6 mg/day)

Hemophilia A & Von Willebrand Disease

IV:

0.3 mcg/kg administered 30 minutes before procedures

Intranasal:

<50 kg: 150 mcg

≥50 kg: 300 mcg

Fluid intake should be restricted from 1 hour before dosing until at least 8 hours after

Renal Dose Adjustment

CrCl <50 mL/min: Contraindicated

CrCl ≥50 mL/min: No dose adjustment required

May be used off-label in uremic bleeding under specialist supervision