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Osteo-D 200000IU/ml Injection
Colecalciferol [Vitamin D3] 200000 IU/ml
- Vitamin D3 Deficiency: Common in people with limited sunlight exposure or deficient diets.
- Bone and Teeth Health: Essential for calcium and phosphate absorption, preventing rickets, osteomalacia, and osteoporosis.
- Pregnancy and Breastfeeding: Prevents pre-eclampsia and supports infant growth.
- Immunity: Boosts immune function.
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✅ Description:
Vitamin D3: A fat-soluble sterol crucial for calcium and phosphate homeostasis and bone mineralization. It facilitates calcium absorption from the gastrointestinal tract and stimulates bone formation.
Vitamin D must be taken with adequate amounts of calcium and magnesium. Insufficient vitamin D and calcium can trigger the parathyroid gland to produce PTH (parathyroid hormone), increasing vitamin D hormone production and calcium mobilization from bones.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses of Osteo-D
- Osteoporosis
- Hypoparathyroidism
- Rickets
- Osteomalacia
- Vitamin D Deficiency
- Pseudohypoparathyroidism
- Familial Hypophosphatemia
✔️ Side Effects of Osteo-D
- Common: Anorexia, lassitude, nausea, vomiting, diarrhea, constipation, weight loss, polyuria, sweating, headache, thirst, vertigo.
- Serious: Elevated plasma and urine calcium and phosphate levels.
✔️ Pharmacology
- Mechanism: Active form, Calcitriol, binds to Vitamin D receptors (VDRs) in various tissues.
- Half-Life: Approximately 50 days.
- Absorption and Metabolism: Absorbed in the small intestine, transported to the liver, converted to Calcidiol, and then to Calcitriol in the kidney.
- Storage and Excretion: Stored in fat and muscle tissues; excreted via feces and urine.
✔️ Dosage & Administration of Osteo-D
Injection
- Prevention:
- Infants: 1/2 ampoule (0.5ml) every 6 months.
- Children up to 5 years: 1 ampoule (1ml) every 6 months.
- Adolescents: 1 ampoule every 6 months during winter.
- Pregnancy: 1/2 ampoule from the 6th/7th month.
- Elderly: 1/2 ampoule every 3 months.
- Specific conditions: 1/2 ampoule or 1 ampoule every 3-6 months.
- Deficiency:
- General: 1 ampoule, repeatable after 1-6 months.
✔️ Interaction
- Increased Hypercalcemia Risk: Thiazide diuretics, calcium, or phosphate.
- Increased Vitamin D Requirements: Antiepileptics (e.g., carbamazepine, phenobarbital, phenytoin, primidone).
- Reduced Efficacy: Rifampicin, isoniazid.
- Counteracting Effects: Corticosteroids.
- Cardiac Glycosides: Increased risk when taken with Digoxin.
- Reduced Absorption: Cholestyramine, colestipol, mineral oil, orlistat.
- Ketoconazole: Possible interaction.
✔️ Contraindications
- Hypercalcemia: Contraindicated in all diseases associated with elevated calcium levels.
- Hypersensitivity: Known hypersensitivity to Colecalciferol or its excipients.
- Vitamin D Toxicity: Evidence of toxicity.
✔️ Pregnancy & Lactation
- Safety: Up to 4,000 IU/day is considered safe.
- Recommended Intake: 400 IU/day, higher if deficient.
- Breastfeeding: Excreted in milk; no observed infant overdose.
✔️ Precautions & Warnings
- Monitoring: Plasma-calcium levels in high doses, renal impairment, and pregnancy.
- Drug Interactions: Consult healthcare providers when using Digoxin, Thiazide diuretics, and for patients with liver/kidney disease, hyperthyroidism, lymphoma, tuberculosis, or granulomatous disease.
- Children (<12 years): Safety and efficacy not established.
✔️ Storage:
- Temperature: Below 30ºC.
- Protection: From light and moisture.
- Safety: Keep out of reach from children.
Disclaimer:
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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