Manisol 20% (500ml)

Introduction

Manisol 20% IV is a medicine used in the treatment of acute renal (kidney) failure, cerebral edema (accumulation of excessive fluid in the brain) and to reduce the pressure inside the eyes in a condition called glaucoma. Manisol 20% IV works by removing excess water and also relieves inflammation in the affected areas. It may be used alone or in combination with other medicines. It is administered as an injection under the supervision of a medical professional and should not be self administered. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. Some common side effects of this medicine include nausea, vomiting, headache, and dehydration. You may also notice some injection site reactions such as pain, redness or swelling. However, these are temporary and usually subside on their own after some time. Please consult your doctor if these do not subside or bother you. Regular monitoring by blood tests may be required while using this medicine.

Uses of Manisol 20% IV

• Acute renal failure
• Cerebral edema (accumulation of excessive fluid in the brain)
• Glaucoma

Side effects of Manisol 20% IV

Common

• Nausea
• Vomiting
• Headache
• Dehydration

How to use Manisol 20% IV

Your doctor or nurse will give you this medicine. Kindly do not self-administer.

How Manisol 20% IV works

Manisol 20% IV is an inert substance with high osmotic pressure. It draws water into the kidney, which in turn increases the amount of urine production. Manisol 20% IV is also used to lower the pressure inside the eye or swelling around the brain.

What if you forget to take Manisol 20% IV?

If you miss a dose of Manisol 20% IV, please consult your doctor.

Quick Tips

• It is given as an injection into the veins by a doctor or healthcare professional.
• Your doctor may get regular blood tests done to monitor sodium and potassium level, kidney function, and lung function while you are taking this medicine.
• Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Brief Description

Indication

Chronic bronchitis, Cerebral oedema, Oliguric phase of renal failure, Raised intracranial pressure, Renal function testing, Transurethral prostatic resection

Adult Dose

Intravenous Oliguric phase of renal failure Adult: 50-100 g in a 24-hr period by IV infusion. Adjust rate of administration to maintain a urine flow of at least 30-50 mL/hr. Cerebral oedema, Reduction of raised intraocular pressure Adult: 0.25-2 g/kg by IV infusion given over 30-60 minutes. Renal function testing Adult: 0.2 g/kg infused over 3-5 min.

Child Dose

Intravenous Edema 0.25-1 g/kg IV initially; maintenance dose of 0.25-0.5 g/kg IV q4-6hr Anuria/Oliguria Test dose: 0.2 g/kg IV over 3-5 minutes; not to exceed 12.5 g Discontinue if no diuresis within 2 hr

Contraindication

Pulmonary congestion or oedema; intracranial bleeding; CHF; metabolic oedema with abnormal capillary fragility; anuria due to severe renal disease; severe dehydration.

Mode of Action

Mannitol increases urinary output by inhibiting tubular reabsorption of water and electrolytes. It raises the osmotic pressure of the plasma allowing water to be drawn out of body tissues.

Precaution

Hypervolaemia; urinary tract obstruction; check for signs of fluid and electrolyte imbalance. Should not be administered with whole blood. Pregnancy, lactation.

Side Effect

Fluid and electrolyte imbalance; acidosis (with high doses). Nausea, vomiting, thirst; headache, dizziness, convulsions, chills, fever; tachycardia, chest pain; blurred vision; urticaria and hypotension or hypertension; acute renal failure; skin necrosis; thrombophloebitis.

Interaction

Increased nephrotoxicity with ciclosporin.