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Zeropain 30mg/ml Injection
- Class: Non-steroidal anti-inflammatory Drug (NSAID).
- Mechanism of Action: Inhibits the cyclooxygenase (COX) enzyme, reducing prostaglandin synthesis. Provides potent analgesic effects with minimal anti-inflammatory action at therapeutic doses.
- Pharmacokinetics:
- Linear pharmacokinetics.
- Highly protein-bound.
- Metabolized primarily in the liver.
- Excreted via urine as metabolites and some unchanged drugs.
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✅ Description:
- Management of moderately severe, acute pain (short-term use only, up to 7 days). Often used in postoperative settings as an alternative to opioid-level analgesia.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses of Zeropain 30mg/ml Injection
Moderate to severe pain
✔️ Side Effects of Zeropain 30mg/ml Injection
- Common: Dyspepsia, nausea, headache, dizziness.
- Serious: GI bleeding, renal impairment, anaphylaxis, cardiovascular thrombotic events.
✔️ How does Zeropain 30mg/ml Injection work?
Ketorolac inhibits prostaglandin synthesis by decreasing the activity of the cyclooxygenase enzyme.
✔️ Quick Suggestions:
- Should not be used for chronic pain or beyond 7 days.
- Use with caution in patients with renal insufficiency, as it can reduce renal function.
- Increased risk of gastrointestinal ulcers, bleeding, and perforation.
- May increase the risk of thrombotic events (e.g., heart attack, stroke).
- Monitor liver function in patients with hepatic disease.
- Avoid in patients with hypersensitivity to NSAIDs, peptic ulcers, or active bleeding.
✔️ Dosage & Administration: Ketorolac Tromethamine IM/IV Injection
Injection (IV or IM):
Single-Dose Treatment:
- IM Dosing (Adults):
- <65 years: 60 mg as a single dose.
- >65 years, renally impaired, or <50 kg body weight: 30 mg as a single dose.
- IV Dosing (Adults):
- <65 years: 30 mg as a single dose.
- >65 years, renally impaired, or <50 kg: 15 mg as a single dose.
- Pediatric Dosing (2-16 years):
- IM: 1 mg/kg (max 30 mg).
- IV: 0.5 mg/kg (max 15 mg).
Multiple-Dose Treatment:
- <65 years: 30 mg every 6 hours (Max: 120 mg/day).
- >65 years, renally impaired, or <50 kg: 15 mg every 6 hours (Max: 60 mg/day).
- Breakthrough Pain: Do not increase dose or frequency.
Conversion from Injection to Oral:
- Total combined daily dose (oral + parenteral) must not exceed:
- 120 mg/day for younger adults.
- 60 mg/day for elderly or renally impaired patients.
- Switch to oral form as soon as feasible.
- Total duration of therapy (oral + parenteral) should not exceed 5 days.
✔️ Interaction
- Other NSAIDs or Aspirin:
- Increases the risk of gastrointestinal and other side effects (e.g., bleeding, ulcers).
- Anticoagulants (e.g., Warfarin):
- Enhances the risk of bleeding due to synergistic effects.
- Beta Blockers:
- May reduce the antihypertensive effect of beta blockers.
- ACE Inhibitors/ARBs:
- Increases the risk of renal dysfunction or impairment.
- Methotrexate:
- Enhances methotrexate toxicity, including nephrotoxicity and myelosuppression.
✔️ Contraindications:
- Hypersensitivity:
- To Ketorolac or other NSAIDs.
- Age Restriction:
- Not to be used in children under 16 years of age.
- Surgical Use:
- Contraindicated for prophylactic analgesia before surgery due to bleeding risk.
- Peptic Ulcer or GI Bleeding:
- Active or suspected conditions are absolute contraindications.
✔️ Pregnancy & Lactation
- Pregnancy:
- Category C (US FDA): Should be avoided unless the benefits outweigh the risks.
- Contraindicated during the third trimester due to the risk of premature closure of the ductus arteriosus in the fetus.
- Lactation:
- Use with caution; insufficient data on excretion in breast milk. Avoid if safer alternatives are available.
✔️ Precautions & Warnings
- Exercise caution in elderly patients (>65 years) due to increased sensitivity to adverse effects.
- Avoid in patients with active or suspected GI ulcers, bleeding, or hepatic dysfunction.
- Use with caution as NSAIDs may exacerbate asthma symptoms.:
- Discontinue immediately if corneal epithelial breakdown occurs.
- Avoid use while wearing contact lenses.
✔️
- Store at room temperature, away from direct light and moisture.
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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