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Finapark 50mg Tablet 1 Strip
Finapark is a monoamine oxidase type B (MAO-B) inhibitor indicated as an adjunctive treatment to levodopa/carbidopa in patients with Parkinson's disease experiencing "off" episodes. It is not effective as a monotherapy for Parkinson’s disease
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Price: ৳ 233
MRP:
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✅ Description:
The exact mechanism of action of Safinamide Mesylate in Parkinson’s disease is not fully understood. Safinamide Mesylate inhibits monoamine oxidase B (MAO-B), which prevents the breakdown of dopamine, resulting in increased dopamine levels and enhanced dopaminergic activity in the brain.
There is limited experience with Safinamide overdose. If an overdose occurs, discontinue treatment and provide supportive care, including dietary restriction of tyramine for several weeks.
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✔️ Side Effects
Common side effects include dyskinesia, falls, nausea, and insomnia.
✔️ Dosage & Administration
- Initial dosage: Start with 50 mg orally once daily at the same time each day. If a dose is missed, take the next dose at the same time the following day.
- Maintenance dosage: After 2 weeks, increase to 100 mg once daily based on individual response and tolerability. If discontinuing 100 mg, reduce the dose to 50 mg for one week before stopping.
- Use in children: The safety and effectiveness of Safinamide in infants and children have not been established.
- Geriatric use: No significant differences in safety or effectiveness between older and younger patients.
- Hepatic impairment: Safinamide plasma concentrations may be elevated in patients with hepatic impairment.
- Use as per the guidance of a registered healthcare professional.
✔️ Interaction
- Selective Serotonin Reuptake Inhibitors (SSRIs): Monitor for serotonin syndrome.
- Sympathomimetic medications: Monitor for hypertension.
- Tyramine-containing foods: Risk of severe hypertension.
- Substrates of Breast Cancer Resistance Protein (BCRP): May increase plasma concentrations of BCRP substrates.
✔️ Safinamide is contraindicated in patients with:
- Concomitant use of other monoamine oxidase inhibitors or potent MAO inhibitors (e.g., linezolid).
- Opioids (e.g., tramadol, meperidine), SNRIs, tricyclic or tetracyclic antidepressants, cyclobenzaprine, methylphenidate, amphetamine, their derivatives, or St. John’s Wort.
- Dextromethorphan.
- History of hypersensitivity to safinamide.
- Severe hepatic impairment (Child-Pugh C).
✔️ Pregnancy & Lactation
- Pregnancy Category C: There are no adequate studies in pregnant women. Animal studies show developmental toxicity, including teratogenic effects.
- It is unknown if Safinamide is excreted in human milk. Due to the potential for serious adverse effects in nursing infants, a decision should be made whether to discontinue breastfeeding or the medication, considering the drug’s importance to the mother.
✔️ Precautions & Warnings
- May cause or worsen hypertension.
- Risk of serotonin syndrome when combined with MAO inhibitors, antidepressants, or opioids.
- Risk of falling asleep during daily activities.
- May exacerbate dyskinesia, consider adjusting the levodopa dose.
- Can cause hallucinations, psychotic behavior, or impulse control issues.
- May lead to withdrawal-emergent hyperpyrexia and confusion.
✔️ Storage:
Store below 30°C, away from light, and out of the reach of children.lofenac Potassium 50 mg Tablet, Acme Laboratories Ltd.
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