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✅ Description:
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Gardasil is a vaccine for the prevention of diseases caused by specific types of Human Papillomavirus (HPV).
For girls and women (ages 9-26):
- Prevention of cervical, vulvar, vaginal, and anal cancers caused by HPV types 16 and 18.
- Prevention of genital warts caused by HPV types 6 and 11.
- Prevention of precancerous lesions:
- Cervical Intraepithelial Neoplasia (CIN) grades 1, 2, and 3.
- Vulvar Intraepithelial Neoplasia (VIN) grades 2 and 3.
- Vaginal Intraepithelial Neoplasia (VaIN) grades 2 and 3.
- Anal Intraepithelial Neoplasia (AIN) grades 1, 2, and 3.
For boys and men (ages 9-45):
- Prevention of anal, oropharyngeal, and other head and neck cancers caused by HPV types 16, 18, 31, 33, 45, 52, and 58.
- Prevention of genital warts caused by HPV types 6 and 11.
- Prevention of precancerous lesions:
- Anal Intraepithelial Neoplasia (AIN) grades 1, 2, and 3.
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Pharmacology
The Gardasil vaccine is based on HPV-like virus particles (L1 VLPs) that stimulate the body’s immune response. The vaccine induces humoral immune responses against HPV types, providing protection against diseases caused by these virus strains. The exact mechanism of protection is not fully understood.
Dosage
For ages 9–14:
- 2-dose schedule: Administered at 0 and 6-12 months.
- If the second dose is given earlier than 5 months after the first, a third dose should be given at least 4 months after the second dose.
- 3-dose schedule: Administered at 0, 2, and 6 months.
For ages 15-45:
- 3-dose schedule: Administered at 0, 2, and 6 months.
Administration
- Intramuscular use only.
- Shake well before use to ensure the vaccine remains properly suspended.
- Administer in the deltoid (upper arm) or the anterolateral thigh.
- Observe for 15 minutes post-vaccination to monitor for syncope.
Interaction
- Immunosuppressive therapies (e.g., corticosteroids, cytotoxic drugs) may reduce immune response to the vaccine.
Contraindications
- Severe allergic reaction (hypersensitivity) to the vaccine or yeast (a component of the vaccine).
Side Effects
Common adverse reactions (≥10% incidence):
- Girls and women (16-26): Injection-site pain (89.9%), swelling (40%), erythema (34%), headache (14.6%).
- Girls (9-15): Injection-site pain (89.3%), swelling (47.8%), erythema (34.1%), headache (11.4%).
- Women (27-45): Injection-site pain (82.8%), swelling (23.3%), erythema (16.9%), headache (13.6%).
- Boys and men (16-26): Injection-site pain (63.4%), swelling (20.2%), erythema (20.7%).
- Boys (9-15): Injection-site pain (71.5%), swelling (26.9%), erythema (24.9%).
Pregnancy & Lactation
- Pregnancy: Category B. No evidence of harm to the fetus in animal studies, but safety during pregnancy has not been well-established. Use only if necessary.
- Lactation: Unknown if excreted in human milk. Caution is advised when administered to nursing women.
Precautions & Warnings
- Syncope: Observe patients for 15 minutes post-vaccination, as fainting can occur.
- Pediatric use: Safety and efficacy not established for children under 9 years.
- Geriatric use: Not evaluated in individuals over 65 years of age.
Overdose Effects
- Overdoses are generally well-tolerated, with adverse effects similar to those reported at recommended doses.
Therapeutic Class
Vaccines, Anti-sera & Immunoglobulin
Storage Conditions
- Refrigerate at 2-8°C.
- Do not freeze.
- Protect from light. Administer as soon as possible after removal from refrigeration.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
