Rabix VC

✔️ Uses of Rabies vaccine

• Prevention of Rabies.

✔️ How does Rabies vaccine work?

It helps develop immunity by forming antibodies, which are proteins that protect against infection caused by viruses.

✔️ Side Effects of Rabies vaccine

• Local reactions: pain, erythema, swelling, itching, and induration.
• Systemic reactions: fever, dizziness, respiratory issues, abdominal pain, vomiting, and allergic reactions.

✔️ Quick Suggestions:

• Rabies vaccine, Human helps prevent rabies.
• It is given as an injection into the muscle of the upper arm.
• If you are at risk of being bitten, the vaccine is given as a course of three injections on days 0, 7, and 28. A booster dose is needed one year after completing this course.
• If you have been immunized against rabies and bitten by an animal suspected of having rabies, two doses of the vaccine are needed, first on the day of the bite and second on day 3 after the bite.
• If you have not been immunized against rabies and bitten by an animal suspected of having rabies, the first injection of rabies vaccine should be given as soon as possible after the bite. This is followed by four further doses on days 3, 7, 14 and 30.
• Do not take Rabies vaccine, Human if you have a weak immune system.

✔️ Indications of Rabix VC

• Prophylactic Immunization:
  • For high-risk professional groups (e.g., veterinary surgeons, laboratory personnel, abattoir workers).
  • For individuals frequently exposed to rabies (e.g., gamekeepers, forestry workers).
  • For infants and others at high risk of rabies.
• Post-exposure Immunization:
  • For those bitten by or in contact with rabid or potentially rabid animals.

✔️ Pharmacology

Rabies Vaccine is a freeze-dried preparation of inactivated rabies virus produced on Vero cells. After reconstitution, it is a clear, colorless sterile solution for intramuscular use.

✔️ Dosage & Administration:

• Reconstitution:
  • Mix the supplied diluent with the freeze-dried preparation without shaking.
  • Ensure the solution is clear and free of particles.
  • Inject immediately and discard the syringe after use.
• Administration:
  • Inject 1 ml intramuscularly into the deltoid muscle for adults or the anterolateral thigh muscle for children under 1 year.
  • Do not inject into the gluteal region or intravenously.

Pre-exposure Immunization:

• Primary Vaccination: 1 ml IM on days 0, 7, 21, or 28, followed by a booster after one year.
• Boosters: Every 5 years or when antibody titer is below 0.5 IU/ml.

Post-exposure Immunization:

• Wound Treatment: Wash thoroughly with soap and water, disinfect, and avoid bandaging or suturing.
• Vaccination for Non-immunized Subjects:
  • Standard IM Regimen: 1 ml on days 0, 3, 7, 14, and 28.
  • Abbreviated Multisite Regimen: 2 injections of 1 ml each on day 0, 1 ml on day 7, and 1 ml on day 21.
• Severe Wounds: Administer rabies immunoglobulin with the first vaccine dose.
• Vaccination for Previously Immunized Subjects:
  • If bitten within 1 year of previous full vaccination: 1 ml on days 0 and 3.
  • If bitten after 1 year: complete post-exposure immunization.

Administration Considerations:

• Avoid using the same syringe and injection site for the vaccine and immunoglobulin.
• Co-administration: Corticosteroids and immunosuppressants may reduce vaccine efficacy; monitor antibody levels.

✔️ Interaction

Immunosuppressants may decrease vaccine effectiveness.

✔️ Contraindications

• Pre-exposure: Severe illness, fever, acute disease, progressive chronic conditions, known hypersensitivity.
• Post-exposure: No absolute contraindications due to the lethal nature of rabies; assess carefully.

✔️ Pregnancy & Lactation

• Pregnancy: Rabies vaccine is not contraindicated due to the disease's severity.
• Lactation: Safety unknown, but not contraindicated due to the disease's severity.

✔️ Precautions & Warnings

• Do not inject intravenously.
• Ensure proper packaging, labeling, and validity before use.
• Use reconstituted vaccine immediately; store in a refrigerator if necessary and use within 8 hours.

✔️ Storage Conditions:

• Keep out of children's reach.
• Store and transport at 2°C to 8°C, protected from light.
• Do not freeze.