Aproxi 40mg Capsule 1 Strip

✔️ Uses of Aproxi 40

• Nausea and vomiting due to chemotherapy

✔️ How does Aproxi 40 work?

Aproxi 40 works by blocking certain chemicals in the body that trigger nausea and vomiting. It is commonly used to prevent sickness caused by medications or cancer treatments like chemotherapy and radiation therapy, helping patients recover more comfortably. Additionally, it is effective in preventing nausea and vomiting following surgery (in adults only). For optimal results, take this medication exactly as prescribed by your doctor.

✔️ Side Effects of Aproxi 40

• Headache
• Dyspepsia
• Fatigue
• Increased Liver Enzymes
• Decreased Appetite
• Constipation

✔️ The dosage recommendations for Aprepitant vary depending on its intended use:

Postoperative Nausea and Vomiting:

• A single 40 mg oral dose should be taken within 3 hours before anesthesia induction.

Chemotherapy-Induced Nausea and Vomiting (CINV):

For highly emetogenic chemotherapy:

• Day 1: Aprepitant 125 mg orally, Dexamethasone 12 mg orally, and a 5-HT3 antagonist (e.g., Ondansetron 24 mg) 30 minutes before chemotherapy.
• Day 2: Aprepitant 80 mg orally, Dexamethasone 8 mg orally.
• Day 3: Aprepitant 80 mg orally, Dexamethasone 8 mg orally.
• Day 4: Dexamethasone 8 mg orally (without Aprepitant).

Aprepitant should be taken 1 hour before chemotherapy on Day 1 and in the morning on Days 2 and 3. Dexamethasone should be taken 30 minutes before chemotherapy on Day 1 and in the morning on Days 2 through 4, considering drug interactions.

For moderately emetogenic chemotherapy:

• Day 1: Aprepitant 125 mg orally, Dexamethasone 12 mg orally, and a 5-HT3 antagonist (Ondansetron 8 mg 30 minutes before chemotherapy, followed by another 8 mg dose 8 hours later).
• Day 2 & 3: Aprepitant 80 mg orally and Ondansetron 8 mg twice daily.

✔️ Interaction

Aprepitant should be taken 1 hour before chemotherapy on Day 1 and in the morning on Days 2 and 3. Dexamethasone is administered 30 minutes before chemotherapy on Day 1, with dose adjustments accounting for drug interactions.

✔️ Interaction

• CYP3A4 Inhibitors (e.g., clarithromycin, diltiazem, verapamil, itraconazole, ritonavir, etc.): These drugs may increase Aprepitant levels, potentially intensifying its effects.
• CYP3A4 Inducers (e.g., carbamazepine, phenytoin, rifampicin, primidone, phenobarbital): These may reduce Aprepitant’s efficacy by accelerating its breakdown.
• CYP2C9 Substrates (e.g., phenytoin, tolbutamide, warfarin): Aprepitant may lower their plasma concentrations, affecting their effectiveness.
• Dexamethasone and Methylprednisolone: Aprepitant can increase their plasma levels, necessitating dose adjustments.
• Benzodiazepines (e.g., midazolam, diazepam, alprazolam): Aprepitant may increase their plasma concentrations, leading to prolonged sedation.
• Colchicine: Its serum levels may rise, increasing the risk of toxicity.
• Chemotherapy Drugs (e.g., docetaxel, paclitaxel, vincristine, etoposide, ifosfamide, imatinib): Aprepitant may enhance their toxicity due to CYP3A4 metabolism interference.
• Ergot Derivatives: Increased levels could lead to ergotism, causing severe vasoconstriction.
• Oral Contraceptives: Aprepitant may reduce their effectiveness; alternative contraception is recommended during treatment and for at least one month after the last dose.
• Potentially Fatal Interactions:
  • Astemizole, cisapride, pimozide, terfenadine: Increased serum levels may cause life-threatening torsade de pointes arrhythmias.

✔️ Contraindications:

Aprepitant is contraindicated in patients who are hypersensitive to any component of the product. Aprepitant should not be used concurrently with Pimozide, Terfenadine, Astemizole or cisapride.

✔️ Pregnancy & Lactation

Pregnancy Category B. This drug should be used during pregnancy only if clearly needed. It is not known whether this drug is excreted in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug based on the patient’s importance.

✔️ Storage:

Store in a cool and dry place away from sunlight