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Zultan 0.024% Ophthalmic Solution 3ml
Latanoprostene bunod reduces intraocular pressure by enhancing aqueous humor outflow via two pathways. This mechanism addresses one of the most modifiable risk factors for glaucoma, thereby minimizing the likelihood of visual field damage.
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✅ Description:
✔️ Indications:
Zultan 0.024% ophthalmic solution is prescribed to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
✔️ Adverse Effects
Common Side Effects (1–10%):
- Hyperemia (6%)
- Eye irritation (4%)
- Eye pain (3%)
- Installation site pain (2%)
Other Reported Reactions:
- Permanent iris pigmentation changes.
- Eyelash growth variations.
✔️ Dosage for Adults
- Reduction of IOP in open-angle glaucoma or ocular hypertension.
- Instill one drop in the affected eye(s) once daily in the evening.
✔️ Dosage for Children
- Reduction of IOP in open-angle glaucoma or ocular hypertension.
- Not recommended Under 16 Years due to safety concerns, such as increased pigmentation from long-term use.
- 16 Years and Older: Instill one drop in the affected eye(s) once daily in the evening.
✔️ Pediatric Use:
- Not recommended for individuals under 16 years old due to safety concerns, such as potential pigmentation changes from prolonged use.
✔️ Geriatric Use:
No significant differences in safety or efficacy were observed between elderly and younger adult patients.
✔️ Warnings and Precautions
- May cause pigmentation changes in the iris and periorbital tissues (eyelids).
- Pigmentation increases with continued use but typically stabilizes after discontinuation.
- While iris pigmentation is likely permanent, changes in the eyelids and eyelashes are usually reversible.
- Regular monitoring is advised for patients showing significant pigmentation changes.
- This may result in increased length, thickness, and number of eyelashes.
- These changes are reversible once the treatment is discontinued.
- Exercise caution in patients with a history of inflammation (iritis/uveitis).
- Avoid use in cases of active intraocular inflammation, as it may worsen the condition.
- Risk of macular edema, including cystoid macular edema, has been reported.
- Use cautiously in patients who are aphakic, pseudophakic with a torn posterior lens capsule, or at risk of macular edema.
- The risk of bacterial keratitis exists due to contamination of multidose containers.
- Higher risk is observed in patients with corneal diseases or disrupted ocular surfaces.
- Contact lenses must be removed before instilling the solution due to the presence of benzalkonium chloride.
- Lenses can be reinserted 15 minutes after application.
✔️ Contraindications
Hypersensitivity to latanoprostene bunod or any of its ingredients.
✔️ Pregnancy & Lactation
Pregnancy:
- No human studies are available.
- Animal studies suggest risks such as fetal harm, miscarriage, and structural abnormalities when administered in high doses.
- Should only be used during pregnancy if clearly needed and after weighing potential risks and benefits.
Lactation:
- No data on excretion in human milk or its effects on the nursing infant.
- The benefits of breastfeeding should be balanced against the mother's need for treatment.
✔️ Storage Guidelines
- Unopened Bottles: Store refrigerated between 2°C and 8°C.
- Opened Bottles: Store between 2°C and 25°C for up to 8 weeks.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
